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Compound
PGDB_C019997
7 activity records1 related patents
2D structure
O=C1CCN(N2Cc3cc(CN4CC5CC4CN5C(c4ccccc4)c4ccccc4)ccc3C2=O)C(=O)N1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % Degradation | - | < | 20 | % | Concentration series: 500 nM, 50 nM | 24 h | IKZF1 | - | - | WO2024245444A1 | PGDB_A007579 | PGDB_C019997 | PGDB_AS000969 | View |
| % Degradation | - | >= | 20 | % | Concentration series: 500 nM, 50 nM | 24 h | IKZF3 | - | - | WO2024245444A1 | PGDB_A008130 | PGDB_C019997 | PGDB_AS001967 | View |
| % Degradation | - | >= | 20 | % | Concentration series: 500 nM, 50 nM | 24 h | WEE1 | - | - | WO2024245444A1 | PGDB_A014528 | PGDB_C019997 | PGDB_AS001444 | View |
| IC50 | - | = | 1.5-1.9 | uM | - | — | CRBN | CRBN | - | WO2024245444A1 | PGDB_A044235 | PGDB_C019997 | PGDB_AS002101 | View |
| % Degradation | - | >= | 20 | % | Concentration series: 500 nM, 50 nM | 24 h | GSPT1 | - | - | WO2024245444A1 | PGDB_A047340 | PGDB_C019997 | PGDB_AS001137 | View |
| % Degradation | - | >= | 20 | % | Concentration series: 500 nM, 50 nM | 24 h | IKZF2 | - | - | WO2024245444A1 | PGDB_A074225 | PGDB_C019997 | PGDB_AS002298 | View |
| % Degradation | - | < | 20 | % | Concentration series: 500 nM, 50 nM | 24 h | CSNK1A1 | - | - | WO2024245444A1 | PGDB_A077187 | PGDB_C019997 | PGDB_AS000339 | View |