PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCN(N2Cc3cc(CN4CC=C(c5cccc(Cl)c5Cl)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C023620

FormulaC24H22Cl2N4O3

Molecular weight485.371

InChIKeyPDXXBGFHIPGHDS-UHFFFAOYSA-N

Physicochemical properties

Exact mass484.1069

RDKit cLogP4.1

TPSA73

HBD / HBA1 / 4

Rotatable bonds4

Heavy atoms33

Hetero atoms9

Rings / aromatic5 / 2

Fraction Csp30.29

Formal charge0

Fragments1

Activity compounds and values

Activity records

14 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	80-100	%	500 nM	-	-	-	MV-4-11	WO2024245444A1	PGDB_A013215	PGDB_C023620	PGDB_AS000199	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2024245444A1	PGDB_A021006	PGDB_C023620	PGDB_AS000339	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2024245444A1	PGDB_A025008	PGDB_C023620	PGDB_AS001967	View
% Inhibition	-	=	18-25	%	10 nM	-	-	-	MV-4-11	WO2024245444A1	PGDB_A030405	PGDB_C023620	PGDB_AS001519	View
% Inhibition	-	=	80-100	%	500 nM	-	-	-	MM.1S	WO2024245444A1	PGDB_A032913	PGDB_C023620	PGDB_AS000503	View
% Inhibition	-	=	20-25	%	10 nM	-	-	-	H2228	WO2024245444A1	PGDB_A036899	PGDB_C023620	PGDB_AS001356	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2024245444A1	PGDB_A037687	PGDB_C023620	PGDB_AS002298	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2024245444A1	PGDB_A045126	PGDB_C023620	PGDB_AS001137	View
% Inhibition	-	=	25-40	%	10 nM	-	-	-	MDA-MB-231	WO2024245444A1	PGDB_A045615	PGDB_C023620	PGDB_AS002156	View
% Inhibition	-	=	40-60	%	500 nM	-	-	-	H2228	WO2024245444A1	PGDB_A045957	PGDB_C023620	PGDB_AS000051	View
% Inhibition	-	=	5-10	%	10 nM	-	-	-	MM.1S	WO2024245444A1	PGDB_A052937	PGDB_C023620	PGDB_AS001568	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2024245444A1	PGDB_A054009	PGDB_C023620	PGDB_AS001444	View
% Inhibition	-	=	80-100	%	500 nM	-	-	-	MDA-MB-231	WO2024245444A1	PGDB_A063405	PGDB_C023620	PGDB_AS002131	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2024245444A1	PGDB_A076023	PGDB_C023620	PGDB_AS000969	View

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