PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1ccc(C2=C(C(=O)N3CCN(Nc4ccc5c(c4F)CN(C4CCC(=O)NC4=O)C5=O)CC3)CCC(C)(C)C2)cc1

Compound summary

Compound IDPGDB_C024191

FormulaC33H38FN5O4

Molecular weight587.696

InChIKeySRSJSRMALLDAKJ-UHFFFAOYSA-N

Physicochemical properties

Exact mass587.2908

RDKit cLogP4.03

TPSA102.1

HBD / HBA2 / 6

Rotatable bonds5

Heavy atoms43

Hetero atoms10

Rings / aromatic6 / 2

Fraction Csp30.45

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	40-50	%	500 nM	96 h	IKZF3	-	A375	WO2025162225A1	PGDB_A007895	PGDB_C024191	PGDB_AS000568	View
% Inhibition	-	=	20-30	%	10 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A025753	PGDB_C024191	PGDB_AS001155	View
% Inhibition	-	=	20-30	%	10 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A027456	PGDB_C024191	PGDB_AS000245	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A029430	PGDB_C024191	PGDB_AS000750	View
% Inhibition	-	=	80-100	%	500 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A030956	PGDB_C024191	PGDB_AS000857	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A036979	PGDB_C024191	PGDB_AS000351	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A046431	PGDB_C024191	PGDB_AS000091	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A051432	PGDB_C024191	PGDB_AS001726	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A058362	PGDB_C024191	PGDB_AS000689	View
% Inhibition	-	=	50-60	%	500 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A063271	PGDB_C024191	PGDB_AS001561	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A064181	PGDB_C024191	PGDB_AS002453	View
% Inhibition	-	=	30-40	%	10 nM	96 h	IKZF3	-	A375	WO2025162225A1	PGDB_A068602	PGDB_C024191	PGDB_AS001349	View

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