PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3c(ccc(NN4CCN(C(c5ccc(F)cc5)c5ccc(F)cc5)CC4)c3F)C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024197

FormulaC30H28F3N5O3

Molecular weight563.58

InChIKeyVMLMKHDNIZZUAM-UHFFFAOYSA-N

Physicochemical properties

Exact mass563.2144

RDKit cLogP3.6

TPSA85

HBD / HBA2 / 6

Rotatable bonds6

Heavy atoms41

Hetero atoms11

Rings / aromatic6 / 3

Fraction Csp30.3

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	40-50	%	10 nM	96 h	IKZF3	-	A375	WO2025162225A1	PGDB_A010392	PGDB_C024197	PGDB_AS001349	View
% Inhibition	-	=	30-40	%	10 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A022720	PGDB_C024197	PGDB_AS000245	View
% Inhibition	-	=	70-80	%	500 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A023231	PGDB_C024197	PGDB_AS000857	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A025308	PGDB_C024197	PGDB_AS000351	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A031481	PGDB_C024197	PGDB_AS000750	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A035717	PGDB_C024197	PGDB_AS002453	View
% Inhibition	-	=	60-70	%	500 nM	96 h	IKZF3	-	A375	WO2025162225A1	PGDB_A038483	PGDB_C024197	PGDB_AS000568	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A039683	PGDB_C024197	PGDB_AS000689	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A053442	PGDB_C024197	PGDB_AS001726	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A056748	PGDB_C024197	PGDB_AS000091	View

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