PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3c(ccc(NN4CCN(CC5=C(c6ccc(F)cc6)CCOC5)CC4)c3F)C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024240

FormulaC29H31F2N5O4

Molecular weight551.594

InChIKeyBFTAPTROWRRIFK-UHFFFAOYSA-N

Physicochemical properties

Exact mass551.2344

RDKit cLogP2.54

TPSA94.2

HBD / HBA2 / 7

Rotatable bonds6

Heavy atoms40

Hetero atoms11

Rings / aromatic6 / 2

Fraction Csp30.41

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	30-40	%	10 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A010182	PGDB_C024240	PGDB_AS001155	View
% Inhibition	-	=	60-70	%	500 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A025085	PGDB_C024240	PGDB_AS000857	View
% Inhibition	-	=	60-70	%	500 nM	96 h	IKZF3	-	A375	WO2025162225A1	PGDB_A028243	PGDB_C024240	PGDB_AS000568	View
% Inhibition	-	=	40-50	%	10 nM	96 h	IKZF3	-	MM.1S	WO2025162225A1	PGDB_A033969	PGDB_C024240	PGDB_AS002484	View
% Inhibition	-	=	50-60	%	500 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A037840	PGDB_C024240	PGDB_AS000866	View
% Inhibition	-	=	30-40	%	10 nM	96 h	IKZF3	-	A375	WO2025162225A1	PGDB_A038725	PGDB_C024240	PGDB_AS001349	View
% Inhibition	-	=	60-70	%	500 nM	96 h	IKZF3	-	MM.1S	WO2025162225A1	PGDB_A040275	PGDB_C024240	PGDB_AS001942	View
% Inhibition	-	=	50-60	%	500 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A058944	PGDB_C024240	PGDB_AS001561	View
% Inhibition	-	=	40-50	%	10 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A063896	PGDB_C024240	PGDB_AS000245	View
% Inhibition	-	=	50-60	%	10 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A075345	PGDB_C024240	PGDB_AS001140	View

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