PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(NN4CC5CN(C(c6ccc(F)cc6)c6ccc(F)cc6)CC5C4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024251

FormulaC32H31F2N5O3

Molecular weight571.628

InChIKeyOMHUYFIODUHMHP-UHFFFAOYSA-N

Physicochemical properties

Exact mass571.2395

RDKit cLogP3.71

TPSA85

HBD / HBA2 / 6

Rotatable bonds6

Heavy atoms42

Hetero atoms10

Rings / aromatic7 / 3

Fraction Csp30.34

Formal charge0

Fragments1

Activity compounds and values

Activity records

14 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	80-100	%	10 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A012560	PGDB_C024251	PGDB_AS001155	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A025284	PGDB_C024251	PGDB_AS000091	View
% Inhibition	-	=	40-50	%	500 nM	96 h	IKZF3	-	RPMI-8226	WO2025162225A1	PGDB_A027378	PGDB_C024251	PGDB_AS001812	View
% Inhibition	-	=	80-100	%	500 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A039668	PGDB_C024251	PGDB_AS001561	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A043221	PGDB_C024251	PGDB_AS000689	View
% Inhibition	-	=	40-50	%	500 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A043672	PGDB_C024251	PGDB_AS000857	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A046889	PGDB_C024251	PGDB_AS000351	View
% Inhibition	-	=	40-53	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A055634	PGDB_C024251	PGDB_AS002133	View
% Inhibition	-	=	30-40	%	10 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A058782	PGDB_C024251	PGDB_AS000245	View
% Inhibition	-	=	80-100	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A066905	PGDB_C024251	PGDB_AS002540	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A072331	PGDB_C024251	PGDB_AS002453	View
% Inhibition	-	=	40-50	%	10 nM	96 h	IKZF3	-	RPMI-8226	WO2025162225A1	PGDB_A073265	PGDB_C024251	PGDB_AS000859	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A073499	PGDB_C024251	PGDB_AS000750	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A076176	PGDB_C024251	PGDB_AS001726	View

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