PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

CC(C)N1CCN(Nc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1

Compound summary

Compound IDPGDB_C024252

FormulaC20H25N5O4

Molecular weight399.451

InChIKeyLKBNPAQUIWLASG-UHFFFAOYSA-N

Physicochemical properties

Exact mass399.1907

RDKit cLogP0.44

TPSA102.1

HBD / HBA2 / 7

Rotatable bonds4

Heavy atoms29

Hetero atoms9

Rings / aromatic4 / 1

Fraction Csp30.5

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A021245	PGDB_C024252	PGDB_AS000689	View
% Inhibition	-	=	10-20	%	10 nM	96 h	IKZF3	-	RPMI-8226	WO2025162225A1	PGDB_A025153	PGDB_C024252	PGDB_AS000859	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A025742	PGDB_C024252	PGDB_AS000351	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A029734	PGDB_C024252	PGDB_AS001726	View
% Inhibition	-	=	60-70	%	500 nM	96 h	IKZF3	-	RPMI-8226	WO2025162225A1	PGDB_A030084	PGDB_C024252	PGDB_AS001812	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A035447	PGDB_C024252	PGDB_AS000091	View
% Inhibition	-	=	30-40	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A048396	PGDB_C024252	PGDB_AS002133	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A048484	PGDB_C024252	PGDB_AS002453	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A069690	PGDB_C024252	PGDB_AS000750	View
% Inhibition	-	=	70-80	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A071203	PGDB_C024252	PGDB_AS002540	View

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