PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)N4CCN(Nc5ccc6c(c5F)CN(C5CCC(=O)NC5=O)C6=O)CC4)cc3)CC2)C1

Compound summary

Compound IDPGDB_C024275

FormulaC43H49ClFN7O4

Molecular weight782.361

InChIKeyLUOZBBJCDPDCIC-UHFFFAOYSA-N

Physicochemical properties

Exact mass781.3519

RDKit cLogP5.81

TPSA108.5

HBD / HBA2 / 8

Rotatable bonds8

Heavy atoms56

Hetero atoms13

Rings / aromatic8 / 3

Fraction Csp30.44

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A024101	PGDB_C024275	PGDB_AS000091	View
% Inhibition	-	>	30	%	0.1 uM	-	IKZF3	-	-	WO2025162225A1	PGDB_A030003	PGDB_C024275	PGDB_AS002324	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A030573	PGDB_C024275	PGDB_AS000351	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A038088	PGDB_C024275	PGDB_AS002453	View
% Inhibition	-	=	40-53	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A039162	PGDB_C024275	PGDB_AS002133	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A049058	PGDB_C024275	PGDB_AS000750	View
% Inhibition	-	=	53-60	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A049971	PGDB_C024275	PGDB_AS002540	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A050379	PGDB_C024275	PGDB_AS000689	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A071499	PGDB_C024275	PGDB_AS001726	View
% Inhibition	-	>	30	%	0.1 uM	-	IKZF3	-	-	WO2025162225A1	PGDB_A073338	PGDB_C024275	PGDB_AS000994	View

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