PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2C(=O)c3ccc(NN4CCN(CC5=C(c6ccc(Cl)cc6)CCNC5)CC4)cc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024280

FormulaC29H31ClN6O4

Molecular weight563.058

InChIKeyHYMYDNHOEIUJKW-UHFFFAOYSA-N

Physicochemical properties

Exact mass562.2095

RDKit cLogP2.13

TPSA114.1

HBD / HBA3 / 8

Rotatable bonds6

Heavy atoms40

Hetero atoms11

Rings / aromatic6 / 2

Fraction Csp30.38

Formal charge0

Fragments1

Activity compounds and values

Activity records

8 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A007777	PGDB_C024280	PGDB_AS000750	View
% Inhibition	-	=	10-20	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A012674	PGDB_C024280	PGDB_AS002133	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A013910	PGDB_C024280	PGDB_AS000689	View
% Inhibition	-	=	53-60	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A022716	PGDB_C024280	PGDB_AS002540	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A025969	PGDB_C024280	PGDB_AS000351	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A035632	PGDB_C024280	PGDB_AS001726	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A055164	PGDB_C024280	PGDB_AS002453	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A063145	PGDB_C024280	PGDB_AS000091	View

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