PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

CC1(C)CCC(C(=O)N2CC3CCC(C2)N3Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1

Compound summary

Compound IDPGDB_C024338

FormulaC34H38ClN5O4

Molecular weight616.162

InChIKeyLUASDFAVCBQKRC-UHFFFAOYSA-N

Physicochemical properties

Exact mass615.2612

RDKit cLogP4.77

TPSA102.1

HBD / HBA2 / 6

Rotatable bonds5

Heavy atoms44

Hetero atoms10

Rings / aromatic7 / 2

Fraction Csp30.47

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	40-53	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A013214	PGDB_C024338	PGDB_AS002133	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A023980	PGDB_C024338	PGDB_AS001726	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A028036	PGDB_C024338	PGDB_AS000351	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A031042	PGDB_C024338	PGDB_AS002453	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A034731	PGDB_C024338	PGDB_AS000750	View
% Inhibition	-	=	40-50	%	10 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A050281	PGDB_C024338	PGDB_AS001155	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A051166	PGDB_C024338	PGDB_AS000689	View
% Inhibition	-	=	80-100	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A056760	PGDB_C024338	PGDB_AS002540	View
% Inhibition	-	=	50-60	%	500 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A070540	PGDB_C024338	PGDB_AS001561	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A075730	PGDB_C024338	PGDB_AS000091	View

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