PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(NN4CCCN(Cc5cnc(-c6ccccc6)cn5)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024343

FormulaC29H31N7O3

Molecular weight525.613

InChIKeyYBQBFFWWPIWEGO-UHFFFAOYSA-N

Physicochemical properties

Exact mass525.2488

RDKit cLogP2.44

TPSA110.8

HBD / HBA2 / 8

Rotatable bonds6

Heavy atoms39

Hetero atoms10

Rings / aromatic6 / 3

Fraction Csp30.34

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A011142	PGDB_C024343	PGDB_AS002453	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A015067	PGDB_C024343	PGDB_AS000750	View
% Inhibition	-	=	60-70	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A015498	PGDB_C024343	PGDB_AS002133	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A022425	PGDB_C024343	PGDB_AS000351	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A041430	PGDB_C024343	PGDB_AS000689	View
% Inhibition	-	=	60-70	%	500 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A042621	PGDB_C024343	PGDB_AS001561	View
% Inhibition	-	=	40-50	%	10 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A056856	PGDB_C024343	PGDB_AS001155	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A062649	PGDB_C024343	PGDB_AS001726	View
% Inhibition	-	=	80-100	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A074961	PGDB_C024343	PGDB_AS002540	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A075595	PGDB_C024343	PGDB_AS000091	View

Rows per pagePage 1 of 1 · 10 recordsGo to page