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Compound
PGDB_C024345
10 activity records1 related patents
2D structure
O=C1CCC(N2Cc3cc(NN4CC5CC4CN5Cc4cnc(-c5ccccc5)cn4)ccc3C2=O)C(=O)N1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % Degradation | - | = | 20-100 | % | Concentration series: 500 nM, 50 nM | 24 h | IKZF3 | - | - | WO2025162225A1 | PGDB_A008851 | PGDB_C024345 | PGDB_AS000351 | View |
| % Degradation | - | = | 20-100 | % | Concentration series: 500 nM, 50 nM | 24 h | IKZF2 | CRBN | - | WO2025162225A1 | PGDB_A024705 | PGDB_C024345 | PGDB_AS000750 | View |
| % Degradation | - | = | 0-20 | % | Concentration series: 500 nM, 50 nM | 24 h | GSPT1 | CRBN | - | WO2025162225A1 | PGDB_A025395 | PGDB_C024345 | PGDB_AS001726 | View |
| % Degradation | - | = | 0-20 | % | Concentration series: 500 nM, 50 nM | 24 h | WEE1 | - | - | WO2025162225A1 | PGDB_A034753 | PGDB_C024345 | PGDB_AS000091 | View |
| % Inhibition | - | = | 80-100 | % | 2 uM | - | CRBN | CRBN | - | WO2025162225A1 | PGDB_A054928 | PGDB_C024345 | PGDB_AS002540 | View |
| % Degradation | - | = | 0-20 | % | Concentration series: 500 nM, 50 nM | 24 h | IKZF1 | CRBN | - | WO2025162225A1 | PGDB_A055477 | PGDB_C024345 | PGDB_AS002453 | View |
| % Inhibition | - | = | 40-53 | % | 0.5 uM | - | CRBN | CRBN | - | WO2025162225A1 | PGDB_A060196 | PGDB_C024345 | PGDB_AS002133 | View |
| % Inhibition | - | = | 50-60 | % | 10 nM | 96 h | IKZF3 | - | MV-4-11 | WO2025162225A1 | PGDB_A064839 | PGDB_C024345 | PGDB_AS001155 | View |
| % Inhibition | - | = | 80-100 | % | 500 nM | 96 h | IKZF3 | - | MV-4-11 | WO2025162225A1 | PGDB_A067494 | PGDB_C024345 | PGDB_AS001561 | View |
| % Degradation | - | = | 20-100 | % | Concentration series: 500 nM, 50 nM | 24 h | CSNK1A1 | - | - | WO2025162225A1 | PGDB_A071976 | PGDB_C024345 | PGDB_AS000689 | View |