PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(NN4CC5CC(C4)N5Cc4ccc(-c5ccncc5)nc4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024352

FormulaC29H29N7O3

Molecular weight523.597

InChIKeyTXSMXCCZJFLLSK-UHFFFAOYSA-N

Physicochemical properties

Exact mass523.2332

RDKit cLogP2.19

TPSA110.8

HBD / HBA2 / 8

Rotatable bonds6

Heavy atoms39

Hetero atoms10

Rings / aromatic8 / 3

Fraction Csp30.34

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	60-70	%	10 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A012071	PGDB_C024352	PGDB_AS001155	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A016526	PGDB_C024352	PGDB_AS001726	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A017891	PGDB_C024352	PGDB_AS000750	View
% Inhibition	-	=	80-100	%	500 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A030697	PGDB_C024352	PGDB_AS001561	View
% Inhibition	-	=	80-100	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A031548	PGDB_C024352	PGDB_AS002540	View
% Inhibition	-	=	70-80	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A032753	PGDB_C024352	PGDB_AS002133	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A042618	PGDB_C024352	PGDB_AS000351	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A048501	PGDB_C024352	PGDB_AS000091	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A068221	PGDB_C024352	PGDB_AS002453	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A076465	PGDB_C024352	PGDB_AS000689	View

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