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Compound
PGDB_C024353
12 activity records1 related patents
2D structure
O=C1CCC(N2Cc3cc(NN4CC5CC4CN5Cc4ccc(-c5ccncc5)nc4)ccc3C2=O)C(=O)N1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % Inhibition | - | = | 80-100 | % | 2 uM | - | CRBN | CRBN | - | WO2025162225A1 | PGDB_A007404 | PGDB_C024353 | PGDB_AS002540 | View |
| % Inhibition | - | = | 30-40 | % | 10 nM | 96 h | IKZF3 | - | MM.1S | WO2025162225A1 | PGDB_A009500 | PGDB_C024353 | PGDB_AS002484 | View |
| % Degradation | - | = | 20-100 | % | Concentration series: 500 nM, 50 nM | 24 h | IKZF3 | - | - | WO2025162225A1 | PGDB_A015879 | PGDB_C024353 | PGDB_AS000351 | View |
| % Degradation | - | = | 20-100 | % | Concentration series: 500 nM, 50 nM | 24 h | IKZF2 | CRBN | - | WO2025162225A1 | PGDB_A021021 | PGDB_C024353 | PGDB_AS000750 | View |
| % Degradation | - | = | 20-100 | % | Concentration series: 500 nM, 50 nM | 24 h | WEE1 | - | - | WO2025162225A1 | PGDB_A034723 | PGDB_C024353 | PGDB_AS000091 | View |
| % Inhibition | - | = | 53-60 | % | 0.5 uM | - | CRBN | CRBN | - | WO2025162225A1 | PGDB_A038477 | PGDB_C024353 | PGDB_AS002133 | View |
| % Inhibition | - | = | 50-60 | % | 500 nM | 96 h | IKZF3 | - | MV-4-11 | WO2025162225A1 | PGDB_A054444 | PGDB_C024353 | PGDB_AS001561 | View |
| % Degradation | - | = | 0-20 | % | Concentration series: 500 nM, 50 nM | 24 h | GSPT1 | CRBN | - | WO2025162225A1 | PGDB_A061095 | PGDB_C024353 | PGDB_AS001726 | View |
| % Inhibition | - | = | 30-40 | % | 10 nM | 96 h | IKZF3 | - | MV-4-11 | WO2025162225A1 | PGDB_A063885 | PGDB_C024353 | PGDB_AS001155 | View |
| % Inhibition | - | = | 40-50 | % | 500 nM | 96 h | IKZF3 | - | MM.1S | WO2025162225A1 | PGDB_A066468 | PGDB_C024353 | PGDB_AS001942 | View |
| % Degradation | - | = | 20-100 | % | Concentration series: 500 nM, 50 nM | 24 h | IKZF1 | CRBN | - | WO2025162225A1 | PGDB_A075576 | PGDB_C024353 | PGDB_AS002453 | View |
| % Degradation | - | = | 20-100 | % | Concentration series: 500 nM, 50 nM | 24 h | CSNK1A1 | - | - | WO2025162225A1 | PGDB_A076816 | PGDB_C024353 | PGDB_AS000689 | View |