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Compound
PGDB_C024379
8 activity records1 related patents
2D structure
CO[C@@]1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCCN(Nc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)C1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % Degradation | - | = | 20-100 | % | Concentration series: 500 nM, 50 nM | 24 h | GSPT1 | CRBN | - | WO2025162225A1 | PGDB_A015074 | PGDB_C024379 | PGDB_AS001726 | View |
| % Degradation | - | = | 20-100 | % | Concentration series: 500 nM, 50 nM | 24 h | WEE1 | - | - | WO2025162225A1 | PGDB_A015123 | PGDB_C024379 | PGDB_AS000091 | View |
| % Degradation | - | = | 20-100 | % | Concentration series: 500 nM, 50 nM | 24 h | IKZF1 | CRBN | - | WO2025162225A1 | PGDB_A021188 | PGDB_C024379 | PGDB_AS002453 | View |
| % Inhibition | - | = | 70-80 | % | 2 uM | - | CRBN | CRBN | - | WO2025162225A1 | PGDB_A023558 | PGDB_C024379 | PGDB_AS002540 | View |
| % Degradation | - | = | 20-100 | % | Concentration series: 500 nM, 50 nM | 24 h | IKZF2 | CRBN | - | WO2025162225A1 | PGDB_A049340 | PGDB_C024379 | PGDB_AS000750 | View |
| % Degradation | - | = | 20-100 | % | Concentration series: 500 nM, 50 nM | 24 h | IKZF3 | - | - | WO2025162225A1 | PGDB_A056902 | PGDB_C024379 | PGDB_AS000351 | View |
| % Degradation | - | = | 20-100 | % | Concentration series: 500 nM, 50 nM | 24 h | CSNK1A1 | - | - | WO2025162225A1 | PGDB_A071994 | PGDB_C024379 | PGDB_AS000689 | View |
| % Inhibition | - | = | 30-40 | % | 0.5 uM | - | CRBN | CRBN | - | WO2025162225A1 | PGDB_A073129 | PGDB_C024379 | PGDB_AS002133 | View |