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Compound
PGDB_C024380
8 activity records1 related patents
2D structure
CC1(C)CCC(CN2CCCN(Nc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(F)cc2)C1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % Degradation | - | = | 20-100 | % | Concentration series: 500 nM, 50 nM | 24 h | IKZF3 | - | - | WO2025162225A1 | PGDB_A010113 | PGDB_C024380 | PGDB_AS000351 | View |
| % Degradation | - | = | 20-100 | % | Concentration series: 500 nM, 50 nM | 24 h | GSPT1 | CRBN | - | WO2025162225A1 | PGDB_A016020 | PGDB_C024380 | PGDB_AS001726 | View |
| % Degradation | - | = | 20-100 | % | Concentration series: 500 nM, 50 nM | 24 h | IKZF1 | CRBN | - | WO2025162225A1 | PGDB_A022242 | PGDB_C024380 | PGDB_AS002453 | View |
| % Degradation | - | = | 20-100 | % | Concentration series: 500 nM, 50 nM | 24 h | IKZF2 | CRBN | - | WO2025162225A1 | PGDB_A038466 | PGDB_C024380 | PGDB_AS000750 | View |
| % Inhibition | - | = | 10-20 | % | 0.5 uM | - | CRBN | CRBN | - | WO2025162225A1 | PGDB_A043026 | PGDB_C024380 | PGDB_AS002133 | View |
| % Degradation | - | = | 20-100 | % | Concentration series: 500 nM, 50 nM | 24 h | CSNK1A1 | - | - | WO2025162225A1 | PGDB_A060019 | PGDB_C024380 | PGDB_AS000689 | View |
| % Inhibition | - | = | 70-80 | % | 2 uM | - | CRBN | CRBN | - | WO2025162225A1 | PGDB_A061357 | PGDB_C024380 | PGDB_AS002540 | View |
| % Degradation | - | = | 0-20 | % | Concentration series: 500 nM, 50 nM | 24 h | WEE1 | - | - | WO2025162225A1 | PGDB_A067336 | PGDB_C024380 | PGDB_AS000091 | View |