PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(NN4CC5CC4CN5CC4=C(c5ccc(F)cc5)CCOC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024397

FormulaC30H32FN5O4

Molecular weight545.615

InChIKeyAUNXMKBFSQHPQF-UHFFFAOYSA-N

Physicochemical properties

Exact mass545.2438

RDKit cLogP2.55

TPSA94.2

HBD / HBA2 / 7

Rotatable bonds6

Heavy atoms40

Hetero atoms10

Rings / aromatic7 / 2

Fraction Csp30.43

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A016488	PGDB_C024397	PGDB_AS000750	View
% Inhibition	-	=	30-40	%	10 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A016781	PGDB_C024397	PGDB_AS001155	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A021251	PGDB_C024397	PGDB_AS002453	View
% Inhibition	-	=	53-60	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A021608	PGDB_C024397	PGDB_AS002133	View
% Inhibition	-	=	80-100	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A044499	PGDB_C024397	PGDB_AS002540	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A047850	PGDB_C024397	PGDB_AS000091	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A072869	PGDB_C024397	PGDB_AS000689	View
% Inhibition	-	=	60-70	%	500 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A073836	PGDB_C024397	PGDB_AS001561	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A075305	PGDB_C024397	PGDB_AS000351	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A075790	PGDB_C024397	PGDB_AS001726	View

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