PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

COC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CC3CC2CN3Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)C1

Compound summary

Compound IDPGDB_C024400

FormulaC33H38ClN5O4

Molecular weight604.151

InChIKeyJIBIYDONXBJRSB-UHFFFAOYSA-N

Physicochemical properties

Exact mass603.2612

RDKit cLogP4.23

TPSA94.2

HBD / HBA2 / 7

Rotatable bonds7

Heavy atoms43

Hetero atoms10

Rings / aromatic7 / 2

Fraction Csp30.48

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	40-50	%	10 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A014735	PGDB_C024400	PGDB_AS001155	View
% Inhibition	-	=	60-70	%	500 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A018726	PGDB_C024400	PGDB_AS001561	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A022428	PGDB_C024400	PGDB_AS000351	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A037988	PGDB_C024400	PGDB_AS001726	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A041785	PGDB_C024400	PGDB_AS000750	View
% Inhibition	-	=	53-60	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A045933	PGDB_C024400	PGDB_AS002133	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A046993	PGDB_C024400	PGDB_AS000091	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A048964	PGDB_C024400	PGDB_AS000689	View
% Inhibition	-	=	80-100	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A063432	PGDB_C024400	PGDB_AS002540	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A066931	PGDB_C024400	PGDB_AS002453	View

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