PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3c(NN4CCN(C(=O)c5ccccc5-c5ccc(Cl)cc5)CC4)cccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024405

FormulaC30H28ClN5O4

Molecular weight558.038

InChIKeyDYHXBTGYUBGAQU-UHFFFAOYSA-N

Physicochemical properties

Exact mass557.183

RDKit cLogP3.55

TPSA102.1

HBD / HBA2 / 6

Rotatable bonds5

Heavy atoms40

Hetero atoms10

Rings / aromatic6 / 3

Fraction Csp30.27

Formal charge0

Fragments1

Activity compounds and values

Activity records

8 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A008734	PGDB_C024405	PGDB_AS002453	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A016503	PGDB_C024405	PGDB_AS000351	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A021628	PGDB_C024405	PGDB_AS001726	View
% Inhibition	-	=	20-30	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A023529	PGDB_C024405	PGDB_AS002133	View
% Inhibition	-	=	60-70	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A034436	PGDB_C024405	PGDB_AS002540	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A044807	PGDB_C024405	PGDB_AS000091	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A058246	PGDB_C024405	PGDB_AS000750	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A066898	PGDB_C024405	PGDB_AS000689	View

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