PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(NN4CCN(CC5=C(c6ccc(Cl)cc6)CCC(F)(F)C5)CC4)c(F)cc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024416

FormulaC30H31ClF3N5O3

Molecular weight602.057

InChIKeyXINHVJZNKZNOPU-UHFFFAOYSA-N

Physicochemical properties

Exact mass601.2068

RDKit cLogP4.46

TPSA85

HBD / HBA2 / 6

Rotatable bonds6

Heavy atoms42

Hetero atoms12

Rings / aromatic6 / 2

Fraction Csp30.43

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A010196	PGDB_C024416	PGDB_AS000351	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A013777	PGDB_C024416	PGDB_AS000689	View
% Inhibition	-	=	30-40	%	10 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A018515	PGDB_C024416	PGDB_AS001140	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A021690	PGDB_C024416	PGDB_AS000750	View
% Inhibition	-	=	10-20	%	10 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A026596	PGDB_C024416	PGDB_AS001155	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A027799	PGDB_C024416	PGDB_AS002453	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A030184	PGDB_C024416	PGDB_AS001726	View
% Inhibition	-	=	30-40	%	10 nM	96 h	IKZF3	-	MM.1S	WO2025162225A1	PGDB_A041319	PGDB_C024416	PGDB_AS002484	View
% Inhibition	-	=	40-50	%	500 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A046803	PGDB_C024416	PGDB_AS000866	View
% Inhibition	-	=	40-50	%	500 nM	96 h	IKZF3	-	MM.1S	WO2025162225A1	PGDB_A049183	PGDB_C024416	PGDB_AS001942	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A063842	PGDB_C024416	PGDB_AS000091	View
% Inhibition	-	=	40-50	%	500 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A071049	PGDB_C024416	PGDB_AS001561	View

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