PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

CC1(C)CCC(C(=O)N2CCN(Nc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1

Compound summary

Compound IDPGDB_C024427

FormulaC32H36ClN5O4

Molecular weight590.124

InChIKeyAVMOXJZKPVZFOC-UHFFFAOYSA-N

Physicochemical properties

Exact mass589.2456

RDKit cLogP4.24

TPSA102.1

HBD / HBA2 / 6

Rotatable bonds5

Heavy atoms42

Hetero atoms10

Rings / aromatic6 / 2

Fraction Csp30.44

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A008275	PGDB_C024427	PGDB_AS000351	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A008551	PGDB_C024427	PGDB_AS002453	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A046017	PGDB_C024427	PGDB_AS000689	View
% Inhibition	-	=	50-60	%	500 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A052966	PGDB_C024427	PGDB_AS001561	View
% Inhibition	-	=	20-30	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A053139	PGDB_C024427	PGDB_AS002133	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A055277	PGDB_C024427	PGDB_AS001726	View
% Inhibition	-	=	53-60	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A056749	PGDB_C024427	PGDB_AS002540	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A058548	PGDB_C024427	PGDB_AS000091	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A063587	PGDB_C024427	PGDB_AS000750	View
% Inhibition	-	=	30-40	%	10 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A064712	PGDB_C024427	PGDB_AS001155	View

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