PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(NN4CCN(C(c5ccccn5)c5ccccn5)CC4)c(F)cc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024433

FormulaC28H28FN7O3

Molecular weight529.576

InChIKeyPATSILIBPYPGPE-UHFFFAOYSA-N

Physicochemical properties

Exact mass529.2238

RDKit cLogP2.11

TPSA110.8

HBD / HBA2 / 8

Rotatable bonds6

Heavy atoms39

Hetero atoms11

Rings / aromatic6 / 3

Fraction Csp30.32

Formal charge0

Fragments1

Activity compounds and values

Activity records

8 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	30-40	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A007819	PGDB_C024433	PGDB_AS002133	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A009393	PGDB_C024433	PGDB_AS000351	View
% Inhibition	-	=	60-70	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A009484	PGDB_C024433	PGDB_AS002540	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A047192	PGDB_C024433	PGDB_AS002453	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A050016	PGDB_C024433	PGDB_AS001726	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A058027	PGDB_C024433	PGDB_AS000091	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A059466	PGDB_C024433	PGDB_AS000750	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A061075	PGDB_C024433	PGDB_AS000689	View

Rows per pagePage 1 of 1 · 8 recordsGo to page