PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(NN4CCCN(C(c5cccc(F)c5)c5cccc(F)c5)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024436

FormulaC31H31F2N5O3

Molecular weight559.617

InChIKeyYRWFWVMVGUZFML-UHFFFAOYSA-N

Physicochemical properties

Exact mass559.2395

RDKit cLogP3.85

TPSA85

HBD / HBA2 / 6

Rotatable bonds6

Heavy atoms41

Hetero atoms10

Rings / aromatic6 / 3

Fraction Csp30.32

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A009856	PGDB_C024436	PGDB_AS000750	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A010562	PGDB_C024436	PGDB_AS001726	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A013250	PGDB_C024436	PGDB_AS000351	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A018889	PGDB_C024436	PGDB_AS002453	View
% Inhibition	-	=	50-60	%	500 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A024390	PGDB_C024436	PGDB_AS001561	View
% Inhibition	-	=	30-40	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A026875	PGDB_C024436	PGDB_AS002133	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A044693	PGDB_C024436	PGDB_AS000091	View
% Inhibition	-	=	30-40	%	10 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A052829	PGDB_C024436	PGDB_AS001155	View
% Inhibition	-	=	60-70	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A052914	PGDB_C024436	PGDB_AS002540	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A073424	PGDB_C024436	PGDB_AS000689	View

Rows per pagePage 1 of 1 · 10 recordsGo to page