PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(NN4CCC5(CC4)CN(C(c4ccccc4F)c4ccccc4F)C5)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024448

FormulaC33H33F2N5O3

Molecular weight585.655

InChIKeyISZWVNWMSSBEKR-UHFFFAOYSA-N

Physicochemical properties

Exact mass585.2551

RDKit cLogP4.24

TPSA85

HBD / HBA2 / 6

Rotatable bonds6

Heavy atoms43

Hetero atoms10

Rings / aromatic7 / 3

Fraction Csp30.36

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	30-40	%	500 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A017342	PGDB_C024448	PGDB_AS001561	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A025145	PGDB_C024448	PGDB_AS002453	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A027817	PGDB_C024448	PGDB_AS000750	View
% Inhibition	-	=	40-50	%	10 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A034756	PGDB_C024448	PGDB_AS001155	View
% Inhibition	-	=	60-70	%	10 nM	96 h	IKZF3	-	MM.1S	WO2025162225A1	PGDB_A043220	PGDB_C024448	PGDB_AS002484	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A045058	PGDB_C024448	PGDB_AS001726	View
% Inhibition	-	=	80-100	%	0.5 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A049910	PGDB_C024448	PGDB_AS002133	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A051242	PGDB_C024448	PGDB_AS000689	View
% Inhibition	-	=	80-100	%	2 uM	-	CRBN	CRBN	-	WO2025162225A1	PGDB_A058674	PGDB_C024448	PGDB_AS002540	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A071796	PGDB_C024448	PGDB_AS000351	View
% Inhibition	-	=	70-80	%	500 nM	96 h	IKZF3	-	MM.1S	WO2025162225A1	PGDB_A073463	PGDB_C024448	PGDB_AS001942	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A076587	PGDB_C024448	PGDB_AS000091	View

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