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Compound
PGDB_C025624
9 activity records1 related patents
2D structure
Cc1nc(N2CCN(Cc3ccc(Cc4ccc5c6c(cccc46)C(=O)N5[C@H]4CCC(=O)NC4=O)cc3)CC2)cc(-n2cnc(C(F)(F)F)c2)n1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DC50 | - | = | 0.37 | nM | - | — | - | - | NCI-H929 | EP4685141A1 | PGDB_A009501 | PGDB_C025624 | PGDB_AS001024 | View |
| IC50 | - | = | 27 | nM | - | — | - | - | - | EP4685141A1 | PGDB_A011053 | PGDB_C025624 | PGDB_AS001840 | View |
| DC50 | - | = | 0.093 | nM | - | — | - | - | NCI-H929 | EP4685141A1 | PGDB_A023820 | PGDB_C025624 | PGDB_AS000575 | View |
| IC50 | - | = | 0.01 | nM | - | — | - | - | NCI-H929 | EP4685141A1 | PGDB_A025529 | PGDB_C025624 | PGDB_AS001501 | View |
| IC50 | - | = | 27 | nM | - | — | - | - | - | EP4685141A1 | PGDB_A038586 | PGDB_C025624 | PGDB_AS000581 | View |
| IC50 | - | = | 27 | nM | - | — | - | - | - | EP4685141A1 | PGDB_A047501 | PGDB_C025624 | PGDB_AS001275 | View |
| Dmax | - | = | 73.2 | % | Concentration series: 1600 nM, 400 nM, 100 nM, 25 nM, 6.25 nM, 1.56 nM, 0.39 nM, 0.1 nM | 24 h | - | - | NCI-H929 | EP4685141A1 | PGDB_A050806 | PGDB_C025624 | PGDB_AS002256 | View |
| Dmax | - | = | 74.1 | % | Concentration series: 1600 nM, 400 nM, 100 nM, 25 nM, 6.25 nM, 1.56 nM, 0.39 nM, 0.1 nM | 24 h | - | - | NCI-H929 | EP4685141A1 | PGDB_A061356 | PGDB_C025624 | PGDB_AS000327 | View |
| IC50 | - | = | 27 | nM | - | — | - | - | - | EP4685141A1 | PGDB_A067574 | PGDB_C025624 | PGDB_AS001083 | View |