PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

C[C@H]1CC2(CCN(c3ccc(C(=O)N4CCC(CN5CCN6c7ncc(N8CCC(=O)NC8=O)cc7OCC[C@H]6C5)CC4)cc3)CC2)CN1c1ccc(C#N)c(Cl)c1

Compound summary

Compound IDPGDB_C030004

FormulaC44H52ClN9O4

Molecular weight806.412

InChIKeyIPDABRXAUMIKLF-ARPOTICCSA-N

Physicochemical properties

Exact mass805.3831

RDKit cLogP5.76

TPSA128.6

HBD / HBA1 / 10

Rotatable bonds6

Heavy atoms58

Hetero atoms14

Rings / aromatic9 / 3

Fraction Csp30.52

Formal charge0

Fragments1

Activity compounds and values

Activity records

15 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	0.007	nM	-	—	AR	-	VCaP	WO2026061104A1	PGDB_A000075	PGDB_C030004	PGDB_AS000271	View
% Degradation	-	=	69	%	5 nM	-	AR	-	VCaP	WO2026061104A1	PGDB_A001087	PGDB_C030004	PGDB_AS001354	View
% Degradation	-	=	92	%	100 nM	-	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A001239	PGDB_C030004	PGDB_AS002389	View
% Degradation	-	=	86	%	50 nM	-	AR	-	VCaP	WO2026061104A1	PGDB_A001331	PGDB_C030004	PGDB_AS001838	View
IC50	-	=	0.003	nM	-	—	AR	-	VCaP	WO2026061104A1	PGDB_A002070	PGDB_C030004	PGDB_AS000271	View
% Degradation	-	=	92	%	100 nM	-	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A002911	PGDB_C030004	PGDB_AS002389	View
% Degradation	-	=	84	%	50 nM	-	AR	-	VCaP	WO2026061104A1	PGDB_A004118	PGDB_C030004	PGDB_AS001838	View
IC50	-	=	0.0065	nM	-	—	AR	-	VCaP	WO2026061104A1	PGDB_A004240	PGDB_C030004	PGDB_AS000271	View
% Degradation	-	=	93	%	10 nM	-	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A005537	PGDB_C030004	PGDB_AS002463	View
% Degradation	-	=	93	%	10 nM	-	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A005806	PGDB_C030004	PGDB_AS002463	View
% Degradation	-	=	94	%	100 nM	-	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A006803	PGDB_C030004	PGDB_AS002389	View
% Degradation	-	=	69	%	5 nM	-	AR	-	VCaP	WO2026061104A1	PGDB_A079526	PGDB_C030004	PGDB_AS001354	View
% Degradation	-	=	84	%	50 nM	-	AR	-	VCaP	WO2026061104A1	PGDB_A080596	PGDB_C030004	PGDB_AS001838	View
% Degradation	-	=	86	%	10 nM	-	AR	-	LNCaPFGC	WO2026061104A1	PGDB_A081170	PGDB_C030004	PGDB_AS002463	View
% Degradation	-	=	81	%	5 nM	-	AR	-	VCaP	WO2026061104A1	PGDB_A081709	PGDB_C030004	PGDB_AS001354	View

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