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Compound
PGDB_C030305
11 activity records1 related patents
2D structure
Nc1nnc(-c2cc(F)ccc2O)cc1N1CC2CCC(C1)N2c1cccc(CN2CCN(CCc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)c1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % Inhibition | - | = | 40-53 | % | 0.5 uM | - | CRBN | CRBN | - | WO2026061475A1 | PGDB_A002092 | PGDB_C030305 | PGDB_AS000662 | View |
| % Degradation | - | <= | 50 | % | Concentration series: 500 nM, 50 nM | - | SMARCA2 | - | MV-4-11 | WO2026061475A1 | PGDB_A003904 | PGDB_C030305 | PGDB_AS002335 | View |
| IC50 | - | = | 10-20 | nM | - | — | - | - | A375 | WO2026061475A1 | PGDB_A004820 | PGDB_C030305 | PGDB_AS002441 | View |
| IC50 | - | <= | 1 | nM | - | — | - | - | H838 | WO2026061475A1 | PGDB_A005322 | PGDB_C030305 | PGDB_AS000282 | View |
| IC50 | - | = | 1-5 | nM | - | — | - | - | H2126 | WO2026061475A1 | PGDB_A005422 | PGDB_C030305 | PGDB_AS001417 | View |
| IC50 | - | = | 10-20 | nM | - | — | - | - | CFPAC-1 | WO2026061475A1 | PGDB_A006230 | PGDB_C030305 | PGDB_AS000179 | View |
| IC50 | - | = | 1-5 | nM | - | — | - | - | H1944 | WO2026061475A1 | PGDB_A006527 | PGDB_C030305 | PGDB_AS001924 | View |
| % Degradation | - | <= | 50 | % | Concentration series: 500 nM, 50 nM | - | SMARCA4 | - | MV-4-11 | WO2026061475A1 | PGDB_A006811 | PGDB_C030305 | PGDB_AS002340 | View |
| IC50 | - | = | 5-10 | nM | - | — | - | - | A549 | WO2026061475A1 | PGDB_A077941 | PGDB_C030305 | PGDB_AS000757 | View |
| % Inhibition | - | = | 80-90 | % | 2 uM | - | CRBN | CRBN | - | WO2026061475A1 | PGDB_A078749 | PGDB_C030305 | PGDB_AS001031 | View |