PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Nc1nnc(-c2cc(F)ccc2O)cc1N1CC2CCC(C1)N2c1ccc(N2CCC(CN3CC4CN(Nc5ccc6c(c5)CN(C5CCC(=O)NC5=O)C6=O)CC4C3)CC2)cc1

Compound summary

Compound IDPGDB_C030414

FormulaC47H54FN11O4

Molecular weight856.02

InChIKeyMUCOZUXKZMRDBS-UHFFFAOYSA-N

Physicochemical properties

Exact mass855.4344

RDKit cLogP4.3

TPSA166.7

HBD / HBA4 / 13

Rotatable bonds9

Heavy atoms63

Hetero atoms16

Rings / aromatic11 / 4

Fraction Csp30.47

Formal charge0

Fragments1

Activity compounds and values

Activity records

11 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	1-5	nM	-	—	-	-	H838	WO2026061475A1	PGDB_A000736	PGDB_C030414	PGDB_AS000282	View
IC50	-	=	5-10	nM	-	—	-	-	H1944	WO2026061475A1	PGDB_A000768	PGDB_C030414	PGDB_AS001924	View
IC50	-	=	200-500	nM	-	—	-	-	H2126	WO2026061475A1	PGDB_A001494	PGDB_C030414	PGDB_AS001417	View
% Inhibition	-	=	90-100	%	2 uM	-	CRBN	CRBN	-	WO2026061475A1	PGDB_A002281	PGDB_C030414	PGDB_AS001031	View
IC50	-	<=	1	nM	-	—	-	-	CFPAC-1	WO2026061475A1	PGDB_A002490	PGDB_C030414	PGDB_AS000179	View
% Degradation	-	<=	50	%	Concentration series: 500 nM, 50 nM	-	SMARCA2	-	MV-4-11	WO2026061475A1	PGDB_A003392	PGDB_C030414	PGDB_AS002335	View
% Inhibition	-	=	53-60	%	0.5 uM	-	CRBN	CRBN	-	WO2026061475A1	PGDB_A004776	PGDB_C030414	PGDB_AS000662	View
IC50	-	=	200-500	nM	-	—	-	-	A375	WO2026061475A1	PGDB_A004971	PGDB_C030414	PGDB_AS002441	View
IC50	-	=	1-5	nM	-	—	-	-	BT549	WO2026061475A1	PGDB_A006130	PGDB_C030414	PGDB_AS002259	View
% Degradation	-	<=	50	%	Concentration series: 500 nM, 50 nM	-	SMARCA4	-	MV-4-11	WO2026061475A1	PGDB_A078458	PGDB_C030414	PGDB_AS002340	View
IC50	-	=	1-5	nM	-	—	-	-	A549	WO2026061475A1	PGDB_A081571	PGDB_C030414	PGDB_AS000757	View

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