PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberAR126418A1

AssigneePlexium

TitleAryl compounds and pharmaceutical compositions that modulate IKZF2

Family ID88679320

Family members1

Filing year2022

JurisdictionAR

Compounds95

Activity records212

Assays7

Activity compounds and values

Activity records

212 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
EC50	-	=	0.026	uM	-	—	IKZF2	CRBN	HEK293T	PGDB_A007974	PGDB_C000416	PGDB_AS001328	View
EC50	-	=	0.014	uM	-	—	IKZF2	CRBN	HEK293T	PGDB_A008065	PGDB_C000471	PGDB_AS001328	View
EC50	-	>	10	uM	-	—	IKZF2	CRBN	HEK293T	PGDB_A008149	PGDB_C000432	PGDB_AS001328	View
% Degradation	-	=	48.8	%	1 uM	24 h	IKZF2	CRBN	HEK293T	PGDB_A008160	PGDB_C000430	PGDB_AS000416	View
DC50	-	=	0.005	uM	-	—	IKZF2	-	HEK293T	PGDB_A009740	PGDB_C000388	PGDB_AS001753	View
% Degradation	-	<	15	%	1 uM	24 h	IKZF2	CRBN	HEK293T	PGDB_A010123	PGDB_C000403	PGDB_AS000416	View
EC50	-	>	10	uM	-	—	IKZF2	CRBN	HEK293T	PGDB_A010176	PGDB_C000449	PGDB_AS001328	View
EC50	-	=	0.011	uM	-	—	IKZF2	CRBN	HEK293T	PGDB_A010779	PGDB_C000408	PGDB_AS001328	View
EC50	-	=	0.006	uM	-	—	IKZF2	CRBN	HEK293T	PGDB_A010818	PGDB_C000462	PGDB_AS001328	View
EC50	-	=	0.037	uM	-	—	IKZF2	CRBN	HEK293T	PGDB_A011234	PGDB_C000419	PGDB_AS001328	View
EC50	-	=	0.008	uM	-	—	IKZF2	CRBN	HEK293T	PGDB_A011396	PGDB_C000460	PGDB_AS001328	View
% Degradation	-	=	82.1	%	1 uM	24 h	IKZF2	-	HEK293T	PGDB_A011731	PGDB_C000388	PGDB_AS002452	View
% Degradation	-	=	42.5	%	1 uM	24 h	IKZF2	CRBN	HEK293T	PGDB_A012335	PGDB_C000416	PGDB_AS000416	View
DC50	-	>	30	uM	-	—	IKZF3	-	HEK293T	PGDB_A012563	PGDB_C000380	PGDB_AS000004	View
EC50	-	=	0.011	uM	-	—	IKZF2	CRBN	HEK293T	PGDB_A013183	PGDB_C000402	PGDB_AS001328	View
EC50	-	>	10	uM	-	—	IKZF2	CRBN	HEK293T	PGDB_A013506	PGDB_C000437	PGDB_AS001328	View
EC50	-	>	10	uM	-	—	IKZF2	CRBN	HEK293T	PGDB_A014063	PGDB_C000440	PGDB_AS001328	View
EC50	-	=	0.015	uM	-	—	IKZF2	CRBN	HEK293T	PGDB_A014314	PGDB_C000409	PGDB_AS001328	View
% Degradation	-	=	86.7	%	1 uM	24 h	IKZF2	CRBN	HEK293T	PGDB_A014928	PGDB_C000399	PGDB_AS000416	View
EC50	-	=	0.042	uM	-	—	IKZF2	CRBN	HEK293T	PGDB_A015449	PGDB_C000396	PGDB_AS001328	View

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