PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

N#Cc1ccc(C2CN([C@H]3CCCC[C@@H]3Oc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)c(Cl)c1

Compound summary

Compound IDPGDB_C000399

FormulaC29H29ClN4O4

Molecular weight533.028

InChIKeyVVAWSIVQULOUDG-ZURQMKNRSA-N

Physicochemical properties

Exact mass532.1877

RDKit cLogP3.76

TPSA102.7

HBD / HBA1 / 6

Rotatable bonds5

Heavy atoms38

Hetero atoms9

Rings / aromatic6 / 2

Fraction Csp30.45

Formal charge0

Fragments1

Activity compounds and values

Activity records

14 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
EC50	-	=	0.045	uM	-	—	CRBN	CRBN	-	US20230265071A1	PGDB_A010776	PGDB_C000399	PGDB_AS001482	View
% Degradation	-	=	86.7	%	1 uM	24 h	IKZF2	CRBN	HEK293T	AR126418A1	PGDB_A014928	PGDB_C000399	PGDB_AS000416	View
EC50	-	=	0.02	uM	-	—	CRBN	CRBN	HEK293T	CN117836288A	PGDB_A017514	PGDB_C000399	PGDB_AS001696	View
% Degradation	-	=	78.9	%	1 uM	24 h	IKZF2	CRBN	HEK293T	CN117836288A	PGDB_A017710	PGDB_C000399	PGDB_AS002458	View
EC50	-	=	0.045	uM	-	—	CRBN	CRBN	HEK293T	CN117836288A	PGDB_A019776	PGDB_C000399	PGDB_AS001696	View
% Degradation	-	=	86.7	%	1 uM	24 h	IKZF2	-	HEK293T	US20230265071A1	PGDB_A031770	PGDB_C000399	PGDB_AS000278	View
EC50	-	=	0.005	uM	-	—	CRBN	CRBN	-	US20230265071A1	PGDB_A033425	PGDB_C000399	PGDB_AS001482	View
% Degradation	-	=	63	%	1 uM	24 h	IKZF2	-	HEK293T	US20230265071A1	PGDB_A052931	PGDB_C000399	PGDB_AS000278	View
EC50	-	=	0.02	uM	-	—	CRBN	CRBN	-	US20230265071A1	PGDB_A060000	PGDB_C000399	PGDB_AS001482	View
EC50	-	=	0.005	uM	-	—	CRBN	CRBN	HEK293T	CN117836288A	PGDB_A060972	PGDB_C000399	PGDB_AS001696	View
% Degradation	-	=	86.7	%	1 uM	24 h	IKZF2	CRBN	HEK293T	CN117836288A	PGDB_A064200	PGDB_C000399	PGDB_AS002458	View
% Degradation	-	=	63	%	1 uM	24 h	IKZF2	CRBN	HEK293T	CN117836288A	PGDB_A070432	PGDB_C000399	PGDB_AS002458	View
% Degradation	-	=	78.9	%	1 uM	24 h	IKZF2	-	HEK293T	US20230265071A1	PGDB_A071731	PGDB_C000399	PGDB_AS000278	View
EC50	-	=	0.005	uM	-	—	IKZF2	CRBN	HEK293T	AR126418A1	PGDB_A077393	PGDB_C000399	PGDB_AS001328	View

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