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Patent
CN121591645A
10 compounds20 activity records2 assays
Patent summary
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | DC50 | - | > | 5 | uM | - | — | GSPT1 | - | 293A | PGDB_A007067 | PGDB_C001073 | PGDB_AS001164 | View |
 | Dmax | - | = | 61 | % | Concentration series: 5000 nM, 1000 nM, 200 nM, 40 nM, 8 nM, 1.6 nM, 0.32 nM, 0.064 nM, 0.0128 nM, 0 nM | 6 h | GSPT1 | - | 293A | PGDB_A008466 | PGDB_C001077 | PGDB_AS000716 | View |
 | DC50 | - | = | 0.522 | uM | - | — | GSPT1 | - | 293A | PGDB_A012411 | PGDB_C001070 | PGDB_AS001164 | View |
 | DC50 | - | = | 0.0193 | uM | - | — | GSPT1 | - | 293A | PGDB_A014521 | PGDB_C001079 | PGDB_AS001164 | View |
 | Dmax | - | = | 34 | % | Concentration series: 5000 nM, 1000 nM, 200 nM, 40 nM, 8 nM, 1.6 nM, 0.32 nM, 0.064 nM, 0.0128 nM, 0 nM | 6 h | GSPT1 | - | 293A | PGDB_A016927 | PGDB_C001078 | PGDB_AS000716 | View |
| Dmax | - | = | 61 | % | Concentration series: 5000 nM, 1000 nM, 200 nM, 40 nM, 8 nM, 1.6 nM, 0.32 nM, 0.064 nM, 0.0128 nM, 0 nM | 6 h | GSPT1 | - | 293A | PGDB_A019445 | PGDB_C001070 | PGDB_AS000716 | View |
| DC50 | - | > | 5 | uM | - | — | GSPT1 | - | 293A | PGDB_A021362 | PGDB_C001078 | PGDB_AS001164 | View |
 | Dmax | - | = | 26 | % | Concentration series: 5000 nM, 1000 nM, 200 nM, 40 nM, 8 nM, 1.6 nM, 0.32 nM, 0.064 nM, 0.0128 nM, 0 nM | 6 h | GSPT1 | - | 293A | PGDB_A023175 | PGDB_C001076 | PGDB_AS000716 | View |
 | DC50 | - | = | 0.00277 | uM | - | — | GSPT1 | - | 293A | PGDB_A024601 | PGDB_C001075 | PGDB_AS001164 | View |
| DC50 | - | = | 0.0695 | uM | - | — | GSPT1 | - | 293A | PGDB_A028248 | PGDB_C001077 | PGDB_AS001164 | View |
 | DC50 | - | = | 0.067 | uM | - | — | GSPT1 | - | 293A | PGDB_A043447 | PGDB_C001074 | PGDB_AS001164 | View |
| DC50 | - | > | 5 | uM | - | — | GSPT1 | - | 293A | PGDB_A043508 | PGDB_C001076 | PGDB_AS001164 | View |
| Dmax | - | = | 29 | % | Concentration series: 5000 nM, 1000 nM, 200 nM, 40 nM, 8 nM, 1.6 nM, 0.32 nM, 0.064 nM, 0.0128 nM, 0 nM | 6 h | GSPT1 | - | 293A | PGDB_A050997 | PGDB_C001073 | PGDB_AS000716 | View |
 | Dmax | - | = | 99.3 | % | Concentration series: 5000 nM, 1000 nM, 200 nM, 40 nM, 8 nM, 1.6 nM, 0.32 nM, 0.064 nM, 0.0128 nM, 0 nM | 6 h | GSPT1 | - | 293A | PGDB_A051270 | PGDB_C001072 | PGDB_AS000716 | View |
| Dmax | - | = | 77 | % | Concentration series: 5000 nM, 1000 nM, 200 nM, 40 nM, 8 nM, 1.6 nM, 0.32 nM, 0.064 nM, 0.0128 nM, 0 nM | 6 h | GSPT1 | - | 293A | PGDB_A057259 | PGDB_C001074 | PGDB_AS000716 | View |
| Dmax | - | = | 99.5 | % | Concentration series: 5000 nM, 1000 nM, 200 nM, 40 nM, 8 nM, 1.6 nM, 0.32 nM, 0.064 nM, 0.0128 nM, 0 nM | 6 h | GSPT1 | - | 293A | PGDB_A062242 | PGDB_C001075 | PGDB_AS000716 | View |
| Dmax | - | = | 73 | % | Concentration series: 5000 nM, 1000 nM, 200 nM, 40 nM, 8 nM, 1.6 nM, 0.32 nM, 0.064 nM, 0.0128 nM, 0 nM | 6 h | GSPT1 | - | 293A | PGDB_A062585 | PGDB_C001079 | PGDB_AS000716 | View |
 | Dmax | - | = | 97.9 | % | Concentration series: 5000 nM, 1000 nM, 200 nM, 40 nM, 8 nM, 1.6 nM, 0.32 nM, 0.064 nM, 0.0128 nM, 0 nM | 6 h | GSPT1 | - | 293A | PGDB_A068868 | PGDB_C001071 | PGDB_AS000716 | View |
| DC50 | - | = | 0.00167 | uM | - | — | GSPT1 | - | 293A | PGDB_A070065 | PGDB_C001072 | PGDB_AS001164 | View |
| DC50 | - | = | 0.00196 | uM | - | — | GSPT1 | - | 293A | PGDB_A071384 | PGDB_C001071 | PGDB_AS001164 | View |