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SIMM · NJU
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SIMM · NJU
Patent
WO2026051943A1
276 compounds
707 activity records
5 assays
Patent summary
Publication number
WO2026051943A1
Assignee
Shanghai Qilu Pharmaceutical Research And Development Centre
Title
Vav1-targeting degradation agent
Family ID
99013210
Family members
1
Family patent IDs
WO2026051943A1
Filing year
2025
Publication date
2026-03-12
Jurisdiction
WO
Compounds
276
Activity records
707
Assays
5
Activity compounds and values
Activity records
705 records
Structure
Metric
Control
Relation
Value
Unit
Concentration
Time
Target
E3
Cell line
Record ID
Compound
Assay
Details
DC50
-
=
2.3
nM
-
—
VAV1
-
-
PGDB_A000001
PGDB_C029684
PGDB_AS001440
View
DC50
-
=
5
nM
-
—
VAV1
-
-
PGDB_A000016
PGDB_C029462
PGDB_AS001440
View
Dmax
-
=
98.44
%
Concentration series: 10 uM, 1 uM
-
VAV1
-
-
PGDB_A000079
PGDB_C029586
PGDB_AS000777
View
DC50
-
=
2.69
nM
-
—
VAV1
-
-
PGDB_A000082
PGDB_C029490
PGDB_AS001440
View
IC50
-
=
0.034
nM
-
—
VAV1
-
pan-T
PGDB_A000131
PGDB_C029568
PGDB_AS000112
View
Dmax
-
=
98.28
%
Concentration series: 10 uM, 1 uM
-
VAV1
-
-
PGDB_A000133
PGDB_C029477
PGDB_AS000777
View
Dmax
-
=
84
%
Concentration series: 10 uM, 1 uM
-
VAV1
-
-
PGDB_A000135
PGDB_C029427
PGDB_AS000777
View
Dmax
-
=
98.6
%
Concentration series: 10 uM, 1 uM
-
VAV1
-
-
PGDB_A000152
PGDB_C029576
PGDB_AS000777
View
DC50
-
=
4.1
nM
-
—
VAV1
-
-
PGDB_A000158
PGDB_C029603
PGDB_AS001440
View
IC50
-
=
0.052
nM
-
—
VAV1
-
pan-T
PGDB_A000163
PGDB_C029593
PGDB_AS000112
View
DC50
-
=
3.3
nM
-
—
VAV1
-
-
PGDB_A000181
PGDB_C029539
PGDB_AS001440
View
IC50
-
=
0.0091
nM
-
—
VAV1
-
pan-T
PGDB_A000187
PGDB_C029492
PGDB_AS000112
View
Dmax
-
=
97.3
%
Concentration series: 10 uM, 1 uM
-
VAV1
-
-
PGDB_A000192
PGDB_C029673
PGDB_AS000777
View
DC50
-
=
3.73
nM
-
—
VAV1
-
-
PGDB_A000205
PGDB_C029432
PGDB_AS001440
View
DC50
-
=
1.2
nM
-
—
VAV1
-
-
PGDB_A000210
PGDB_C029661
PGDB_AS001440
View
Dmax
-
=
97.3
%
Concentration series: 10 uM, 1 uM
-
VAV1
-
-
PGDB_A000220
PGDB_C029444
PGDB_AS000777
View
Dmax
-
=
98.6
%
Concentration series: 10 uM, 1 uM
-
VAV1
-
-
PGDB_A000224
PGDB_C029606
PGDB_AS000777
View
DC50
-
=
0.8
nM
-
—
VAV1
-
-
PGDB_A000234
PGDB_C029569
PGDB_AS001440
View
IC50
-
=
0.23
nM
-
—
VAV1
-
pan-T
PGDB_A000245
PGDB_C029477
PGDB_AS000112
View
Dmax
-
=
96.58
%
Concentration series: 10 uM, 1 uM
-
VAV1
-
-
PGDB_A000273
PGDB_C029530
PGDB_AS000777
View
