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Compound
PGDB_C000645
6 activity records2 related patents
2D structure
N#Cc1cccc(-c2cnc(N3CCC(CNCc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3)c(F)c2)c1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % Degradation | - | = | 98 | % | 10 nM | 24 h | GSPT1 | - | HL-60 | WO2023116835A1 | PGDB_A023984 | PGDB_C000645 | PGDB_AS000871 | View |
| % Degradation | - | = | 94 | % | 10 nM | - | - | - | HL-60 | CN117982498A | PGDB_A033483 | PGDB_C000645 | PGDB_AS001270 | View |
| % Degradation | - | = | 94 | % | 10 nM | 24 h | MYC | - | HL-60 | WO2023116835A1 | PGDB_A055341 | PGDB_C000645 | PGDB_AS002563 | View |
| IC50 | - | = | 1.3 | nM | - | — | - | - | HL-60 | CN117982498A | PGDB_A061938 | PGDB_C000645 | PGDB_AS001350 | View |
| % Degradation | - | = | 98 | % | 10 nM | 24 h | - | - | HL-60 | CN117982498A | PGDB_A062324 | PGDB_C000645 | PGDB_AS001212 | View |
| IC50 | - | = | 1.3 | nM | - | — | - | - | HL-60 | WO2023116835A1 | PGDB_A075724 | PGDB_C000645 | PGDB_AS000718 | View |