PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2023116835A1

AssigneeSuzhou Kintor Pharmaceuticals

TitleMulti-protein degradation agent having imide skeleton

Family ID86901333

Family members5

Filing year2022

Publication date2024-10-30

JurisdictionWO

Compounds171

Activity records260

Assays5

Activity compounds and values

Activity records

260 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
IC50	-	=	0.2	nM	-	—	-	-	HL-60	PGDB_A007107	PGDB_C000593	PGDB_AS000718	View
IC50	-	=	106	nM	-	—	-	-	HL-60	PGDB_A007680	PGDB_C000655	PGDB_AS000718	View
IC50	-	<	0.2	nM	-	—	-	-	HL-60	PGDB_A007732	PGDB_C000577	PGDB_AS000718	View
% Degradation	-	=	57	%	10 nM	24 h	MYC	-	HL-60	PGDB_A007749	PGDB_C000579	PGDB_AS002563	View
IC50	-	=	0.2	nM	-	—	-	-	HL-60	PGDB_A008632	PGDB_C000588	PGDB_AS000718	View
IC50	-	<	0.2	nM	-	—	-	-	HL-60	PGDB_A008892	PGDB_C000614	PGDB_AS000718	View
% Degradation	-	=	89	%	10 nM	24 h	MYC	-	HL-60	PGDB_A008939	PGDB_C000621	PGDB_AS002563	View
% Degradation	-	=	83	%	10 nM	24 h	MYC	-	HL-60	PGDB_A009657	PGDB_C000540	PGDB_AS002563	View
% Degradation	-	=	5	%	10 nM	24 h	MYC	-	HL-60	PGDB_A009713	PGDB_C001985	PGDB_AS002563	View
% Degradation	-	=	81	%	10 nM	24 h	MYC	-	HL-60	PGDB_A009808	PGDB_C000559	PGDB_AS002563	View
IC50	-	<	0.2	nM	-	—	-	-	HL-60	PGDB_A010098	PGDB_C000615	PGDB_AS000718	View
IC50	-	=	1.2	nM	-	—	-	-	HL-60	PGDB_A010145	PGDB_C000568	PGDB_AS000718	View
IC50	-	=	0.1	nM	-	—	-	-	HL-60	PGDB_A010238	PGDB_C000628	PGDB_AS000718	View
% Degradation	-	=	100	%	10 nM	24 h	GSPT1	-	HL-60	PGDB_A010369	PGDB_C000644	PGDB_AS000871	View
IC50	-	=	0.3	nM	-	—	-	-	HL-60	PGDB_A010732	PGDB_C000584	PGDB_AS000718	View
IC50	-	=	12	nM	-	—	-	-	HL-60	PGDB_A010838	PGDB_C002012	PGDB_AS000718	View
% Degradation	-	=	93	%	10 nM	24 h	GSPT1	-	HL-60	PGDB_A012580	PGDB_C000639	PGDB_AS000871	View
IC50	-	=	1097	nM	-	—	-	-	HL-60	PGDB_A012742	PGDB_C002005	PGDB_AS000718	View
IC50	-	=	0.6	nM	-	—	-	-	HL-60	PGDB_A013196	PGDB_C000621	PGDB_AS000718	View
IC50	-	=	5211	nM	-	—	-	-	HL-60	PGDB_A013706	PGDB_C002022	PGDB_AS000718	View

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