PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CN4CCC(N5CCN(C(c6ccccc6)c6ccccc6)CC5)C(F)(F)C4)cc(F)c3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C000760

FormulaC36H38F3N5O3

Molecular weight645.726

InChIKeyPHPAEVAXSBDUED-UHFFFAOYSA-N

Physicochemical properties

Exact mass645.2927

RDKit cLogP4.2

TPSA76.2

HBD / HBA1 / 6

Rotatable bonds7

Heavy atoms47

Hetero atoms11

Rings / aromatic7 / 3

Fraction Csp30.42

Formal charge0

Fragments1

Activity compounds and values

Activity records

7 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	CN120548310A	PGDB_A024209	PGDB_C000760	PGDB_AS001466	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	CN120548310A	PGDB_A026157	PGDB_C000760	PGDB_AS002025	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	CN120548310A	PGDB_A033952	PGDB_C000760	PGDB_AS000946	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	CN120548310A	PGDB_A038801	PGDB_C000760	PGDB_AS000102	View
IC50	-	=	0.5-1	uM	-	—	CRBN	CRBN	-	CN120548310A	PGDB_A041929	PGDB_C000760	PGDB_AS000323	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	CN120548310A	PGDB_A043552	PGDB_C000760	PGDB_AS001655	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	CN120548310A	PGDB_A043600	PGDB_C000760	PGDB_AS001449	View

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