PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3c(ccc(CN4CCC(N5CCN(C(c6ccccc6)c6ccccn6)CC5)C(F)(F)C4)c3F)C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C000792

FormulaC35H37F3N6O3

Molecular weight646.714

InChIKeyWESXQOGPYFPXFL-UHFFFAOYSA-N

Physicochemical properties

Exact mass646.2879

RDKit cLogP3.6

TPSA89.1

HBD / HBA1 / 7

Rotatable bonds7

Heavy atoms47

Hetero atoms12

Rings / aromatic7 / 3

Fraction Csp30.43

Formal charge0

Fragments1

Activity compounds and values

Activity records

16 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	50-60	%	1 uM	24 h	-	-	-	CN120548310A	PGDB_A017008	PGDB_C000792	PGDB_AS000202	View
% Inhibition	-	=	50-60	%	1 uM	24 h	-	-	-	CN120548310A	PGDB_A018905	PGDB_C000792	PGDB_AS000115	View
% Inhibition	-	=	53-60	%	0.5 uM	-	CRBN	CRBN	-	CN120548310A	PGDB_A030075	PGDB_C000792	PGDB_AS002000	View
% Inhibition	-	=	60-70	%	0.1 uM	24 h	-	-	-	CN120548310A	PGDB_A030684	PGDB_C000792	PGDB_AS001714	View
% Inhibition	-	=	30-40	%	0.1 uM	24 h	-	-	-	CN120548310A	PGDB_A031983	PGDB_C000792	PGDB_AS002390	View
% Inhibition	-	=	70-80	%	1 uM	24 h	-	-	-	CN120548310A	PGDB_A036911	PGDB_C000792	PGDB_AS000296	View
% Inhibition	-	=	80-90	%	1 uM	24 h	-	-	-	CN120548310A	PGDB_A037599	PGDB_C000792	PGDB_AS001951	View
% Inhibition	-	=	60-70	%	0.1 uM	24 h	-	-	-	CN120548310A	PGDB_A037756	PGDB_C000792	PGDB_AS000650	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	CN120548310A	PGDB_A054599	PGDB_C000792	PGDB_AS000946	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	CN120548310A	PGDB_A056367	PGDB_C000792	PGDB_AS000102	View
% Inhibition	-	=	60-70	%	2 uM	-	CRBN	CRBN	-	CN120548310A	PGDB_A058562	PGDB_C000792	PGDB_AS001462	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	CN120548310A	PGDB_A068470	PGDB_C000792	PGDB_AS001466	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	CN120548310A	PGDB_A071558	PGDB_C000792	PGDB_AS002025	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	CN120548310A	PGDB_A071738	PGDB_C000792	PGDB_AS001449	View
% Inhibition	-	=	40-50	%	0.1 uM	24 h	-	-	-	CN120548310A	PGDB_A071851	PGDB_C000792	PGDB_AS001835	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	CN120548310A	PGDB_A072534	PGDB_C000792	PGDB_AS001655	View

Rows per pagePage 1 of 1 · 16 recordsGo to page