PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cccc(CN4CCC(N5CCN(C(c6ccccc6)c6ccccn6)CC5)C(F)(F)C4)c3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C000796

FormulaC35H38F2N6O3

Molecular weight628.724

InChIKeyUTICBIKQTGZBNF-UHFFFAOYSA-N

Physicochemical properties

Exact mass628.2973

RDKit cLogP3.46

TPSA89.1

HBD / HBA1 / 7

Rotatable bonds7

Heavy atoms46

Hetero atoms11

Rings / aromatic7 / 3

Fraction Csp30.43

Formal charge0

Fragments1

Activity compounds and values

Activity records

14 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	20-30	%	1 uM	24 h	-	-	-	CN120548310A	PGDB_A013739	PGDB_C000796	PGDB_AS000125	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	CN120548310A	PGDB_A014156	PGDB_C000796	PGDB_AS000946	View
% Inhibition	-	=	50-60	%	0.1 uM	24 h	-	-	-	CN120548310A	PGDB_A014182	PGDB_C000796	PGDB_AS001320	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	CN120548310A	PGDB_A020210	PGDB_C000796	PGDB_AS000102	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	CN120548310A	PGDB_A020574	PGDB_C000796	PGDB_AS001655	View
% Inhibition	-	=	40-50	%	1 uM	24 h	-	-	-	CN120548310A	PGDB_A022673	PGDB_C000796	PGDB_AS000157	View
% Inhibition	-	=	50-60	%	0.1 uM	24 h	-	-	-	CN120548310A	PGDB_A024553	PGDB_C000796	PGDB_AS000584	View
% Inhibition	-	=	30-40	%	1 uM	24 h	-	-	-	CN120548310A	PGDB_A037122	PGDB_C000796	PGDB_AS000115	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	CN120548310A	PGDB_A041976	PGDB_C000796	PGDB_AS001466	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	CN120548310A	PGDB_A050094	PGDB_C000796	PGDB_AS001449	View
% Inhibition	-	=	53-60	%	2 uM	-	CRBN	CRBN	-	CN120548310A	PGDB_A058993	PGDB_C000796	PGDB_AS001462	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	CN120548310A	PGDB_A060404	PGDB_C000796	PGDB_AS002025	View
% Inhibition	-	=	20-30	%	0.5 uM	-	CRBN	CRBN	-	CN120548310A	PGDB_A062375	PGDB_C000796	PGDB_AS002000	View
% Inhibition	-	=	40-50	%	0.1 uM	24 h	-	-	-	CN120548310A	PGDB_A071965	PGDB_C000796	PGDB_AS002390	View

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