PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CCCN4CCC(N5CC=C(c6cccc(Cl)c6Cl)CC5)C(F)(F)C4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C000849

FormulaC32H34Cl2F2N4O3

Molecular weight631.551

InChIKeyANPNDNPCLPGWQK-UHFFFAOYSA-N

Physicochemical properties

Exact mass630.1976

RDKit cLogP5.19

TPSA73

HBD / HBA1 / 5

Rotatable bonds7

Heavy atoms43

Hetero atoms11

Rings / aromatic6 / 2

Fraction Csp30.47

Formal charge0

Fragments1

Activity compounds and values

Activity records

14 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	30-40	%	10 nM	-	-	-	SW620	CN120548310A	PGDB_A013141	PGDB_C000849	PGDB_AS001642	View
% Inhibition	-	=	40-53	%	0.5 uM	-	CRBN	CRBN	-	CN120548310A	PGDB_A014622	PGDB_C000849	PGDB_AS002000	View
% Inhibition	-	=	50-60	%	10 nM	-	-	-	MOLT-4	CN120548310A	PGDB_A014944	PGDB_C000849	PGDB_AS001814	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	CN120548310A	PGDB_A018827	PGDB_C000849	PGDB_AS001466	View
% Inhibition	-	=	60-70	%	2 uM	-	CRBN	CRBN	-	CN120548310A	PGDB_A027470	PGDB_C000849	PGDB_AS001462	View
% Inhibition	-	=	40-50	%	500 nM	-	-	-	SW620	CN120548310A	PGDB_A028157	PGDB_C000849	PGDB_AS001503	View
% Inhibition	-	=	80-100	%	500 nM	-	-	-	MOLT-4	CN120548310A	PGDB_A032260	PGDB_C000849	PGDB_AS000553	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	CN120548310A	PGDB_A037379	PGDB_C000849	PGDB_AS001449	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	CN120548310A	PGDB_A037637	PGDB_C000849	PGDB_AS002025	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	CN120548310A	PGDB_A038675	PGDB_C000849	PGDB_AS001655	View
% Inhibition	-	=	60-70	%	10 nM	96 h	-	-	MM.1S	CN120548310A	PGDB_A040821	PGDB_C000849	PGDB_AS000332	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	CN120548310A	PGDB_A046791	PGDB_C000849	PGDB_AS000102	View
% Inhibition	-	=	80-100	%	500 nM	96 h	-	-	MM.1S	CN120548310A	PGDB_A054644	PGDB_C000849	PGDB_AS001316	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	CN120548310A	PGDB_A059970	PGDB_C000849	PGDB_AS000946	View

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