PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3c(ccc(CN4CCC(N5CCN(c6noc7cc(F)ccc67)CC5)C(F)(F)C4)c3F)C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C000863

FormulaC30H30F4N6O4

Molecular weight614.6

InChIKeyDTZQCBZLFZPJMT-UHFFFAOYSA-N

Physicochemical properties

Exact mass614.2265

RDKit cLogP2.9

TPSA102.2

HBD / HBA1 / 8

Rotatable bonds5

Heavy atoms44

Hetero atoms14

Rings / aromatic7 / 3

Fraction Csp30.47

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	CN120548310A	PGDB_A007322	PGDB_C000863	PGDB_AS002025	View
% Inhibition	-	=	53-60	%	2 uM	-	CRBN	CRBN	-	CN120548310A	PGDB_A014376	PGDB_C000863	PGDB_AS001462	View
% Inhibition	-	=	60-70	%	500 nM	96 h	-	-	MM.1S	CN120548310A	PGDB_A014422	PGDB_C000863	PGDB_AS001316	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	CN120548310A	PGDB_A016896	PGDB_C000863	PGDB_AS000102	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	CN120548310A	PGDB_A025988	PGDB_C000863	PGDB_AS001449	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	CN120548310A	PGDB_A040036	PGDB_C000863	PGDB_AS001655	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	CN120548310A	PGDB_A043811	PGDB_C000863	PGDB_AS000946	View
% Inhibition	-	=	40-53	%	0.5 uM	-	CRBN	CRBN	-	CN120548310A	PGDB_A070835	PGDB_C000863	PGDB_AS002000	View
% Inhibition	-	=	32-42	%	10 nM	96 h	-	-	MM.1S	CN120548310A	PGDB_A072755	PGDB_C000863	PGDB_AS000332	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	CN120548310A	PGDB_A077527	PGDB_C000863	PGDB_AS001466	View

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