PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3c(C(=O)N4CCC(N5CCN(C(c6ccccc6)c6ccccc6)CC5)C(F)(F)C4)cccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C000884

FormulaC36H37F2N5O4

Molecular weight641.719

InChIKeyQWSUCWKQBWUOQA-UHFFFAOYSA-N

Physicochemical properties

Exact mass641.2814

RDKit cLogP3.7

TPSA93.3

HBD / HBA1 / 6

Rotatable bonds6

Heavy atoms47

Hetero atoms11

Rings / aromatic7 / 3

Fraction Csp30.39

Formal charge0

Fragments1

Activity compounds and values

Activity records

8 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	53-60	%	2 uM	-	CRBN	CRBN	-	CN120548310A	PGDB_A015126	PGDB_C000884	PGDB_AS001462	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	CN120548310A	PGDB_A015492	PGDB_C000884	PGDB_AS002025	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	CN120548310A	PGDB_A023297	PGDB_C000884	PGDB_AS001655	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	CN120548310A	PGDB_A026915	PGDB_C000884	PGDB_AS000102	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	CN120548310A	PGDB_A029374	PGDB_C000884	PGDB_AS000946	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	CN120548310A	PGDB_A037138	PGDB_C000884	PGDB_AS001449	View
% Inhibition	-	=	10-20	%	0.5 uM	-	CRBN	CRBN	-	CN120548310A	PGDB_A075244	PGDB_C000884	PGDB_AS002000	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	CN120548310A	PGDB_A075658	PGDB_C000884	PGDB_AS001466	View

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