PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(C(=O)N4CCC(N5CCN(c6noc7cc(F)ccc67)CC5)C(F)(F)C4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C000933

FormulaC30H29F3N6O5

Molecular weight610.593

InChIKeyCBXIQRNVJJVKIY-UHFFFAOYSA-N

Physicochemical properties

Exact mass610.2152

RDKit cLogP2.4

TPSA119.3

HBD / HBA1 / 8

Rotatable bonds4

Heavy atoms44

Hetero atoms14

Rings / aromatic7 / 3

Fraction Csp30.43

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	CN120548310A	PGDB_A022662	PGDB_C000933	PGDB_AS000946	View
% Inhibition	-	=	53-60	%	2 uM	-	CRBN	CRBN	-	CN120548310A	PGDB_A030766	PGDB_C000933	PGDB_AS001462	View
% Inhibition	-	=	5-10	%	10 nM	-	-	-	MOLT-4	CN120548310A	PGDB_A043767	PGDB_C000933	PGDB_AS001814	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	CN120548310A	PGDB_A047214	PGDB_C000933	PGDB_AS001655	View
% Inhibition	-	=	50-60	%	500 nM	-	-	-	MOLT-4	CN120548310A	PGDB_A055301	PGDB_C000933	PGDB_AS000553	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	CN120548310A	PGDB_A062564	PGDB_C000933	PGDB_AS001466	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	CN120548310A	PGDB_A066787	PGDB_C000933	PGDB_AS000102	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	CN120548310A	PGDB_A068131	PGDB_C000933	PGDB_AS001449	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	CN120548310A	PGDB_A070568	PGDB_C000933	PGDB_AS002025	View
% Inhibition	-	=	30-40	%	0.5 uM	-	CRBN	CRBN	-	CN120548310A	PGDB_A073150	PGDB_C000933	PGDB_AS002000	View

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