PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(C(=O)N4CCC(N5CC=C(c6cccc(Cl)c6Cl)CC5)C(F)(F)C4)cc(F)c3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C000955

FormulaC30H27Cl2F3N4O4

Molecular weight635.47

InChIKeyBVMJWFLQPIXXIV-UHFFFAOYSA-N

Physicochemical properties

Exact mass634.1361

RDKit cLogP4.53

TPSA90

HBD / HBA1 / 5

Rotatable bonds4

Heavy atoms43

Hetero atoms13

Rings / aromatic6 / 2

Fraction Csp30.4

Formal charge0

Fragments1

Activity compounds and values

Activity records

8 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	CN120548310A	PGDB_A013235	PGDB_C000955	PGDB_AS000946	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	CN120548310A	PGDB_A022163	PGDB_C000955	PGDB_AS001449	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	CN120548310A	PGDB_A028455	PGDB_C000955	PGDB_AS001655	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	CN120548310A	PGDB_A039003	PGDB_C000955	PGDB_AS002025	View
% Inhibition	-	=	30-40	%	0.5 uM	-	CRBN	CRBN	-	CN120548310A	PGDB_A039351	PGDB_C000955	PGDB_AS002000	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	CN120548310A	PGDB_A046240	PGDB_C000955	PGDB_AS001466	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	CN120548310A	PGDB_A061720	PGDB_C000955	PGDB_AS000102	View
% Inhibition	-	=	60-70	%	2 uM	-	CRBN	CRBN	-	CN120548310A	PGDB_A065350	PGDB_C000955	PGDB_AS001462	View

Rows per pagePage 1 of 1 · 8 recordsGo to page