PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

CC1(C)Cc2cc(-c3ccc(-c4cn(C5CCC(=O)NC5=O)c(=O)o4)c(F)c3)nc(N)c2O1

Compound summary

Compound IDPGDB_C010125

FormulaC23H21FN4O5

Molecular weight452.442

InChIKeyZMLKQUYYZBYSNQ-UHFFFAOYSA-N

Physicochemical properties

Exact mass452.1496

RDKit cLogP2.58

TPSA129.4

HBD / HBA2 / 8

Rotatable bonds3

Heavy atoms33

Hetero atoms10

Rings / aromatic5 / 3

Fraction Csp30.3

Formal charge0

Fragments1

Activity compounds and values

Activity records

26 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
Dmax	-	=	98	%	-	20 h	IKZF2	-	-	WO2025049840	PGDB_A014522	PGDB_C010125	PGDB_AS002476	View
Dmax	-	=	63	%	-	24 h	IKZF1	-	Jurkat	WO2025049840	PGDB_A018876	PGDB_C010125	PGDB_AS000717	View
Dmax	-	=	76	%	-	-	IKZF3	-	-	WO2025049840	PGDB_A021411	PGDB_C010125	PGDB_AS001160	View
DC50	-	=	600	nM	-	—	IKZF3	-	Jurkat	WO2025049840	PGDB_A024902	PGDB_C010125	PGDB_AS000098	View
DC50	-	=	45	nM	-	—	IKZF2	-	-	WO2025049840	PGDB_A027053	PGDB_C010125	PGDB_AS001132	View
DC50	-	=	2	nM	-	—	IKZF4	-	-	WO2025049840	PGDB_A028152	PGDB_C010125	PGDB_AS001336	View
Dmax	-	=	22	%	-	20 h	IKZF3	-	-	WO2025049840	PGDB_A030674	PGDB_C010125	PGDB_AS001955	View
% Degradation	-	=	76	%	Concentration context: titrated doses	24 h	-	-	primary human PBMC	WO2025049840	PGDB_A037494	PGDB_C010125	PGDB_AS001028	View
DC50	-	=	55	nM	-	—	IKZF4	-	-	WO2025049840	PGDB_A040838	PGDB_C010125	PGDB_AS000023	View
Dmax	-	=	55	%	-	24 h	IKZF3	-	Jurkat	WO2025049840	PGDB_A044268	PGDB_C010125	PGDB_AS000726	View
Dmax	-	=	51	%	-	20 h	IKZF1	-	-	WO2025049840	PGDB_A044783	PGDB_C010125	PGDB_AS001762	View
DC50	-	=	22	nM	-	—	IKZF2	-	Jurkat	WO2025049840	PGDB_A044903	PGDB_C010125	PGDB_AS002487	View
Dmax	-	=	89	%	-	-	IKZF2	-	Jurkat	WO2025049840	PGDB_A045781	PGDB_C010125	PGDB_AS000207	View
Dmax	-	=	56	%	-	20 h	IKZF4	-	-	WO2025049840	PGDB_A046757	PGDB_C010125	PGDB_AS000341	View
Dmax	-	=	89	%	-	24 h	IKZF2	-	Jurkat	WO2025049840	PGDB_A053296	PGDB_C010125	PGDB_AS001341	View
Dmax	-	=	84	%	-	13 d	IKZF4	-	-	WO2025049840	PGDB_A057424	PGDB_C010125	PGDB_AS000200	View
Dmax	-	=	76	%	-	-	IKZF1	-	-	WO2025049840	PGDB_A060132	PGDB_C010125	PGDB_AS001079	View
% Degradation	-	=	76	%	Concentration context: titrated doses	24 h	IKZF1	-	-	WO2025049840	PGDB_A061645	PGDB_C010125	PGDB_AS000316	View
DC50	-	>	10000	nM	-	—	IKZF3	-	-	WO2025049840	PGDB_A062690	PGDB_C010125	PGDB_AS001695	View
Dmax	-	=	84	%	-	-	IKZF4	-	-	WO2025049840	PGDB_A064368	PGDB_C010125	PGDB_AS001208	View

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