PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

CO[C@H]1C[C@H](Oc2c(C)cc(-c3ccc(-c4cn(C5CCC(=O)NC5=O)c(=O)o4)c(F)c3)nc2N)C1

Compound summary

Compound IDPGDB_C010126

FormulaC25H25FN4O6

Molecular weight496.495

InChIKeyKLWWIJBBBDWGRY-VNHLFDKOSA-N

Physicochemical properties

Exact mass496.1758

RDKit cLogP2.73

TPSA138.7

HBD / HBA2 / 9

Rotatable bonds6

Heavy atoms36

Hetero atoms11

Rings / aromatic5 / 3

Fraction Csp30.36

Formal charge0

Fragments1

Activity compounds and values

Activity records

26 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
Dmax	-	=	56	%	-	20 h	IKZF1	-	-	WO2025049840	PGDB_A008882	PGDB_C010126	PGDB_AS001762	View
DC50	-	=	37	nM	-	—	IKZF2	-	Jurkat	WO2025049840	PGDB_A009930	PGDB_C010126	PGDB_AS002487	View
Dmax	-	=	98	%	-	20 h	IKZF2	-	-	WO2025049840	PGDB_A010166	PGDB_C010126	PGDB_AS002476	View
Dmax	-	=	48	%	-	24 h	IKZF3	-	Jurkat	WO2025049840	PGDB_A010979	PGDB_C010126	PGDB_AS000726	View
Dmax	-	=	74	%	-	13 d	IKZF2	-	-	WO2025049840	PGDB_A014897	PGDB_C010126	PGDB_AS001641	View
DC50	-	=	950	nM	-	—	IKZF1	-	-	WO2025049840	PGDB_A016010	PGDB_C010126	PGDB_AS001718	View
Dmax	-	=	92	%	-	24 h	IKZF2	-	Jurkat	WO2025049840	PGDB_A016030	PGDB_C010126	PGDB_AS001341	View
Dmax	-	=	58	%	-	-	IKZF3	-	-	WO2025049840	PGDB_A016414	PGDB_C010126	PGDB_AS001160	View
% Degradation	-	=	58	%	Concentration context: titrated doses	24 h	-	-	primary human PBMC	WO2025049840	PGDB_A017639	PGDB_C010126	PGDB_AS001028	View
DC50	-	=	3	nM	-	—	IKZF4	-	-	WO2025049840	PGDB_A019186	PGDB_C010126	PGDB_AS001336	View
Dmax	-	=	72	%	-	-	IKZF4	-	-	WO2025049840	PGDB_A026446	PGDB_C010126	PGDB_AS001208	View
DC50	-	=	2320	nM	-	—	IKZF3	-	Jurkat	WO2025049840	PGDB_A026536	PGDB_C010126	PGDB_AS000098	View
DC50	-	=	132	nM	-	—	-	-	primary human PBMC	WO2025049840	PGDB_A033455	PGDB_C010126	PGDB_AS001952	View
DC50	-	>	10000	nM	-	—	IKZF3	-	-	WO2025049840	PGDB_A034897	PGDB_C010126	PGDB_AS001695	View
Dmax	-	=	64	%	-	24 h	IKZF1	-	Jurkat	WO2025049840	PGDB_A045139	PGDB_C010126	PGDB_AS000717	View
DC50	-	=	4380	nM	-	—	IKZF1	-	Jurkat	WO2025049840	PGDB_A047007	PGDB_C010126	PGDB_AS002315	View
Dmax	-	=	62	%	-	20 h	IKZF4	-	-	WO2025049840	PGDB_A047928	PGDB_C010126	PGDB_AS000341	View
DC50	-	=	205	nM	-	—	IKZF2	-	-	WO2025049840	PGDB_A048936	PGDB_C010126	PGDB_AS001132	View
Dmax	-	=	25	%	-	20 h	IKZF3	-	-	WO2025049840	PGDB_A055918	PGDB_C010126	PGDB_AS001955	View
DC50	-	=	86	nM	-	—	IKZF3	-	-	WO2025049840	PGDB_A058119	PGDB_C010126	PGDB_AS002428	View

Rows per pagePage 1 of 2 · 26 recordsGo to page