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Compound
PGDB_C010914
6 activity records1 related patents
2D structure
Fc1ccc2nc(CNc3cc(N4C5CCC4CNC5)nn4c(C(F)(F)F)cnc34)[nH]c2c1FCompound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50 | - | <= | 0.05 | uM | - | — | - | - | MDA-MB-231 | WO2025110815A1 | PGDB_A037344 | PGDB_C010914 | PGDB_AS000344 | View |
| IC50 | - | <= | 0.1 | uM | - | — | CDK13 | - | - | WO2025110815A1 | PGDB_A044965 | PGDB_C010914 | PGDB_AS001146 | View |
| IC50 | - | <= | 0.3 | uM | - | — | POLR2A | - | - | WO2025110815A1 | PGDB_A045759 | PGDB_C010914 | PGDB_AS000589 | View |
| Selectivity index | CDK2 / CDK12 | = | 100-500 | fold | - | — | - | - | - | WO2025110815A1 | PGDB_A046907 | PGDB_C010914 | PGDB_AS002325 | View |
| IC50 | - | <= | 0.1 | uM | - | — | CDK12 | - | - | WO2025110815A1 | PGDB_A050865 | PGDB_C010914 | PGDB_AS002095 | View |
| Selectivity index | CDK1 / CDK12 | = | 100-500 | fold | - | — | - | - | - | WO2025110815A1 | PGDB_A062527 | PGDB_C010914 | PGDB_AS002417 | View |