Loading compound
Loading detail record from the SQLite release...
Compound
PGDB_C010944
8 activity records1 related patents
2D structure
OC1CN(c2cc(NCc3nc4cc(Cl)c(Cl)cc4[nH]3)c3ncc(C(F)(F)F)n3n2)C1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selectivity index | CDK2 / CDK12 | = | 100-500 | fold | - | — | - | - | - | WO2025110815A1 | PGDB_A016073 | PGDB_C010944 | PGDB_AS002325 | View |
| Selectivity index | CDK2 / CDK12 | = | 100-500 | fold | - | — | - | - | - | WO2025110815A1 | PGDB_A023313 | PGDB_C010944 | PGDB_AS002325 | View |
| Selectivity index | CDK1 / CDK12 | = | 100-500 | fold | - | — | - | - | - | WO2025110815A1 | PGDB_A024844 | PGDB_C010944 | PGDB_AS002417 | View |
| IC50 | - | <= | 0.3 | uM | - | — | POLR2A | - | - | WO2025110815A1 | PGDB_A029795 | PGDB_C010944 | PGDB_AS000589 | View |
| IC50 | - | <= | 0.1 | uM | - | — | CDK13 | - | - | WO2025110815A1 | PGDB_A036032 | PGDB_C010944 | PGDB_AS001146 | View |
| Selectivity index | CDK1 / CDK12 | = | 100-500 | fold | - | — | - | - | - | WO2025110815A1 | PGDB_A039600 | PGDB_C010944 | PGDB_AS002417 | View |
| IC50 | - | <= | 0.1 | uM | - | — | CDK12 | - | - | WO2025110815A1 | PGDB_A076381 | PGDB_C010944 | PGDB_AS002095 | View |
| IC50 | - | = | 0.05-0.5 | uM | - | — | - | - | MDA-MB-231 | WO2025110815A1 | PGDB_A077835 | PGDB_C010944 | PGDB_AS000344 | View |