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Compound
PGDB_C010951
8 activity records1 related patents
2D structure
FC(F)(F)c1cnc2c(NCc3nc4cc(Cl)c(Cl)cc4[nH]3)cc(N3CCOCC3)nn12Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selectivity index | CDK2 / CDK12 | <= | 100 | fold | - | — | - | - | - | WO2025110815A1 | PGDB_A011851 | PGDB_C010951 | PGDB_AS002325 | View |
| Selectivity index | CDK1 / CDK12 | <= | 100 | fold | - | — | - | - | - | WO2025110815A1 | PGDB_A019733 | PGDB_C010951 | PGDB_AS002417 | View |
| Selectivity index | CDK2 / CDK12 | <= | 100 | fold | - | — | - | - | - | WO2025110815A1 | PGDB_A045492 | PGDB_C010951 | PGDB_AS002325 | View |
| IC50 | - | <= | 0.1 | uM | - | — | CDK13 | - | - | WO2025110815A1 | PGDB_A048463 | PGDB_C010951 | PGDB_AS001146 | View |
| IC50 | - | <= | 0.05 | uM | - | — | - | - | MDA-MB-231 | WO2025110815A1 | PGDB_A048908 | PGDB_C010951 | PGDB_AS000344 | View |
| IC50 | - | = | 0.1-0.5 | uM | - | — | CDK12 | - | - | WO2025110815A1 | PGDB_A059481 | PGDB_C010951 | PGDB_AS002095 | View |
| Selectivity index | CDK1 / CDK12 | <= | 100 | fold | - | — | - | - | - | WO2025110815A1 | PGDB_A060717 | PGDB_C010951 | PGDB_AS002417 | View |
| IC50 | - | <= | 0.3 | uM | - | — | POLR2A | - | - | WO2025110815A1 | PGDB_A071336 | PGDB_C010951 | PGDB_AS000589 | View |