Loading compound
Loading detail record from the SQLite release...
Compound
PGDB_C010952
8 activity records1 related patents
2D structure
FC(F)(F)c1cnc2c(NCc3nc4ccccc4[nH]3)cc(N3CCOCC3)nn12Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selectivity index | CDK1 / CDK12 | = | 100-500 | fold | - | — | - | - | - | WO2025110815A1 | PGDB_A007998 | PGDB_C010952 | PGDB_AS002417 | View |
| Selectivity index | CDK1 / CDK12 | = | 100-500 | fold | - | — | - | - | - | WO2025110815A1 | PGDB_A013838 | PGDB_C010952 | PGDB_AS002417 | View |
| IC50 | - | = | 0.05-0.5 | uM | - | — | - | - | MDA-MB-231 | WO2025110815A1 | PGDB_A025872 | PGDB_C010952 | PGDB_AS000344 | View |
| Selectivity index | CDK2 / CDK12 | = | 100-500 | fold | - | — | - | - | - | WO2025110815A1 | PGDB_A026320 | PGDB_C010952 | PGDB_AS002325 | View |
| IC50 | - | <= | 0.1 | uM | - | — | CDK13 | - | - | WO2025110815A1 | PGDB_A053454 | PGDB_C010952 | PGDB_AS001146 | View |
| IC50 | - | <= | 0.1 | uM | - | — | CDK12 | - | - | WO2025110815A1 | PGDB_A063468 | PGDB_C010952 | PGDB_AS002095 | View |
| IC50 | - | = | 0.3-3 | uM | - | — | POLR2A | - | - | WO2025110815A1 | PGDB_A075523 | PGDB_C010952 | PGDB_AS000589 | View |
| Selectivity index | CDK2 / CDK12 | = | 100-500 | fold | - | — | - | - | - | WO2025110815A1 | PGDB_A075614 | PGDB_C010952 | PGDB_AS002325 | View |