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Compound
PGDB_C010959
8 activity records1 related patents
2D structure
Fc1cccc2[nH]c(CNc3cc(N4CCOCC4)nn4c(C(F)(F)F)cnc34)nc12Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selectivity index | CDK2 / CDK12 | > | 500 | fold | - | — | - | - | - | WO2025110815A1 | PGDB_A011011 | PGDB_C010959 | PGDB_AS002325 | View |
| Selectivity index | CDK1 / CDK12 | > | 500 | fold | - | — | - | - | - | WO2025110815A1 | PGDB_A015839 | PGDB_C010959 | PGDB_AS002417 | View |
| IC50 | - | <= | 0.05 | uM | - | — | - | - | MDA-MB-231 | WO2025110815A1 | PGDB_A018455 | PGDB_C010959 | PGDB_AS000344 | View |
| IC50 | - | <= | 0.1 | uM | - | — | CDK13 | - | - | WO2025110815A1 | PGDB_A026102 | PGDB_C010959 | PGDB_AS001146 | View |
| IC50 | - | <= | 0.1 | uM | - | — | CDK12 | - | - | WO2025110815A1 | PGDB_A039667 | PGDB_C010959 | PGDB_AS002095 | View |
| Selectivity index | CDK1 / CDK12 | > | 500 | fold | - | — | - | - | - | WO2025110815A1 | PGDB_A055730 | PGDB_C010959 | PGDB_AS002417 | View |
| Selectivity index | CDK2 / CDK12 | > | 500 | fold | - | — | - | - | - | WO2025110815A1 | PGDB_A064040 | PGDB_C010959 | PGDB_AS002325 | View |
| IC50 | - | <= | 0.3 | uM | - | — | POLR2A | - | - | WO2025110815A1 | PGDB_A069469 | PGDB_C010959 | PGDB_AS000589 | View |