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Compound
PGDB_C010960
8 activity records1 related patents
2D structure
Fc1ccc2[nH]c(CNc3cc(N4CCOCC4)nn4c(C(F)(F)F)cnc34)nc2c1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selectivity index | CDK1 / CDK12 | > | 500 | fold | - | — | - | - | - | WO2025110815A1 | PGDB_A008572 | PGDB_C010960 | PGDB_AS002417 | View |
| Selectivity index | CDK2 / CDK12 | = | 100-500 | fold | - | — | - | - | - | WO2025110815A1 | PGDB_A017436 | PGDB_C010960 | PGDB_AS002325 | View |
| IC50 | - | <= | 0.1 | uM | - | — | CDK13 | - | - | WO2025110815A1 | PGDB_A030245 | PGDB_C010960 | PGDB_AS001146 | View |
| Selectivity index | CDK1 / CDK12 | > | 500 | fold | - | — | - | - | - | WO2025110815A1 | PGDB_A033565 | PGDB_C010960 | PGDB_AS002417 | View |
| IC50 | - | <= | 0.1 | uM | - | — | CDK12 | - | - | WO2025110815A1 | PGDB_A034862 | PGDB_C010960 | PGDB_AS002095 | View |
| Selectivity index | CDK2 / CDK12 | = | 100-500 | fold | - | — | - | - | - | WO2025110815A1 | PGDB_A038429 | PGDB_C010960 | PGDB_AS002325 | View |
| IC50 | - | <= | 0.05 | uM | - | — | - | - | MDA-MB-231 | WO2025110815A1 | PGDB_A041818 | PGDB_C010960 | PGDB_AS000344 | View |
| IC50 | - | <= | 0.3 | uM | - | — | POLR2A | - | - | WO2025110815A1 | PGDB_A061485 | PGDB_C010960 | PGDB_AS000589 | View |